Toward carbon-nanotube-based theranostic agents for microwave detection and treatment of breast cancer: Enhanced dielectric and heating response of tissue-mimicking materials

Alireza Mashal; Balaji Sitharaman; Xu Li; Pramod K. Avti; Alan V. Sahakian; John H. Booske; Susan C. Hagness

doi:10.1109/TBME.2010.2042597

Toward carbon-nanotube-based theranostic agents for microwave detection and treatment of breast cancer: Enhanced dielectric and heating response of tissue-mimicking materials

Alireza Mashal^*, Balaji Sitharaman, Xu Li, Pramod K. Avti, Alan V. Sahakian, John H. Booske, Susan C. Hagness

^*Corresponding author for this work

Electrical and Computer Engineering

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

The experimental results reported in this paper suggest that single-walled carbon nanotubes (SWCNTs) have the potential to enhance dielectric contrast between malignant and normal tissue for microwave detection of breast cancer and facilitate selective heating of malignant tissue for microwave hyperthermia treatment of breast cancer. In this study, we constructed tissue-mimicking materials with varying concentrations of SWCNTs and characterized their dielectric properties and heating response. At SWCNT concentrations of less than 0.5% by weight, we observed significant increases in the relative permittivity and effective conductivity. In microwave heating experiments, we observed significantly greater temperature increases in mixtures containing SWCNTs. These temperature increases scaled linearly with the effective conductivity of the mixtures. This work is a first step towards the development of functionalized, tumor-targeting SWCNTs as theranostic (integrated therapeutic and diagnostic) agents for microwave breast cancer detection and treatment.

Original language	English (US)
Article number	5416291
Pages (from-to)	1831-1834
Number of pages	4
Journal	IEEE Transactions on Biomedical Engineering
Volume	57
Issue number	8
DOIs	https://doi.org/10.1109/TBME.2010.2042597
State	Published - Aug 2010

Funding

Manuscript received December 22, 2009; revised January 24, 2010; accepted January 31, 2010. Date of publication February 18, 2010; date of current version July 14, 2010. This work was supported by the Department of Defense Breast Cancer Research Program under Grant W81XWH-07-1-0629, by the National Institutes of Health under Grant R01CA112398 awarded by the National Cancer Institute, and by the Carol M. Baldwin Breast Cancer Research Fund. Asterisk indicates corresponding author.

Keywords

Breast cancer
carbon nanotubes
contrast agent
dielectric spectroscopy
microwave hyperthermia
microwave imaging
phantoms

ASJC Scopus subject areas

Biomedical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/TBME.2010.2042597

Cite this

Mashal, A., Sitharaman, B., Li, X., Avti, P. K., Sahakian, A. V., Booske, J. H., & Hagness, S. C. (2010). Toward carbon-nanotube-based theranostic agents for microwave detection and treatment of breast cancer: Enhanced dielectric and heating response of tissue-mimicking materials. IEEE Transactions on Biomedical Engineering, 57(8), 1831-1834. Article 5416291. https://doi.org/10.1109/TBME.2010.2042597

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title = "Toward carbon-nanotube-based theranostic agents for microwave detection and treatment of breast cancer: Enhanced dielectric and heating response of tissue-mimicking materials",

abstract = "The experimental results reported in this paper suggest that single-walled carbon nanotubes (SWCNTs) have the potential to enhance dielectric contrast between malignant and normal tissue for microwave detection of breast cancer and facilitate selective heating of malignant tissue for microwave hyperthermia treatment of breast cancer. In this study, we constructed tissue-mimicking materials with varying concentrations of SWCNTs and characterized their dielectric properties and heating response. At SWCNT concentrations of less than 0.5% by weight, we observed significant increases in the relative permittivity and effective conductivity. In microwave heating experiments, we observed significantly greater temperature increases in mixtures containing SWCNTs. These temperature increases scaled linearly with the effective conductivity of the mixtures. This work is a first step towards the development of functionalized, tumor-targeting SWCNTs as theranostic (integrated therapeutic and diagnostic) agents for microwave breast cancer detection and treatment.",

keywords = "Breast cancer, carbon nanotubes, contrast agent, dielectric spectroscopy, microwave hyperthermia, microwave imaging, phantoms",

author = "Alireza Mashal and Balaji Sitharaman and Xu Li and Avti, {Pramod K.} and Sahakian, {Alan V.} and Booske, {John H.} and Hagness, {Susan C.}",

note = "Funding Information: Manuscript received December 22, 2009; revised January 24, 2010; accepted January 31, 2010. Date of publication February 18, 2010; date of current version July 14, 2010. This work was supported by the Department of Defense Breast Cancer Research Program under Grant W81XWH-07-1-0629, by the National Institutes of Health under Grant R01CA112398 awarded by the National Cancer Institute, and by the Carol M. Baldwin Breast Cancer Research Fund. Asterisk indicates corresponding author.",

year = "2010",

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doi = "10.1109/TBME.2010.2042597",

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Mashal, A, Sitharaman, B, Li, X, Avti, PK, Sahakian, AV, Booske, JH & Hagness, SC 2010, 'Toward carbon-nanotube-based theranostic agents for microwave detection and treatment of breast cancer: Enhanced dielectric and heating response of tissue-mimicking materials', IEEE Transactions on Biomedical Engineering, vol. 57, no. 8, 5416291, pp. 1831-1834. https://doi.org/10.1109/TBME.2010.2042597

Toward carbon-nanotube-based theranostic agents for microwave detection and treatment of breast cancer: Enhanced dielectric and heating response of tissue-mimicking materials. / Mashal, Alireza; Sitharaman, Balaji; Li, Xu et al.
In: IEEE Transactions on Biomedical Engineering, Vol. 57, No. 8, 5416291, 08.2010, p. 1831-1834.

Research output: Contribution to journal › Article › peer-review

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AU - Mashal, Alireza

AU - Sitharaman, Balaji

AU - Li, Xu

AU - Avti, Pramod K.

AU - Sahakian, Alan V.

AU - Booske, John H.

AU - Hagness, Susan C.

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N2 - The experimental results reported in this paper suggest that single-walled carbon nanotubes (SWCNTs) have the potential to enhance dielectric contrast between malignant and normal tissue for microwave detection of breast cancer and facilitate selective heating of malignant tissue for microwave hyperthermia treatment of breast cancer. In this study, we constructed tissue-mimicking materials with varying concentrations of SWCNTs and characterized their dielectric properties and heating response. At SWCNT concentrations of less than 0.5% by weight, we observed significant increases in the relative permittivity and effective conductivity. In microwave heating experiments, we observed significantly greater temperature increases in mixtures containing SWCNTs. These temperature increases scaled linearly with the effective conductivity of the mixtures. This work is a first step towards the development of functionalized, tumor-targeting SWCNTs as theranostic (integrated therapeutic and diagnostic) agents for microwave breast cancer detection and treatment.

AB - The experimental results reported in this paper suggest that single-walled carbon nanotubes (SWCNTs) have the potential to enhance dielectric contrast between malignant and normal tissue for microwave detection of breast cancer and facilitate selective heating of malignant tissue for microwave hyperthermia treatment of breast cancer. In this study, we constructed tissue-mimicking materials with varying concentrations of SWCNTs and characterized their dielectric properties and heating response. At SWCNT concentrations of less than 0.5% by weight, we observed significant increases in the relative permittivity and effective conductivity. In microwave heating experiments, we observed significantly greater temperature increases in mixtures containing SWCNTs. These temperature increases scaled linearly with the effective conductivity of the mixtures. This work is a first step towards the development of functionalized, tumor-targeting SWCNTs as theranostic (integrated therapeutic and diagnostic) agents for microwave breast cancer detection and treatment.

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KW - contrast agent

KW - dielectric spectroscopy

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KW - microwave imaging

KW - phantoms

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Toward carbon-nanotube-based theranostic agents for microwave detection and treatment of breast cancer: Enhanced dielectric and heating response of tissue-mimicking materials

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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