Toward design-based engineering of industrial microbes

Keith EJ Tyo*, Kanokarn Kocharin, Jens Nielsen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations

Abstract

Engineering industrial microbes has been hampered by incomplete knowledge of cell biology. Thus an iterative engineering cycle of modeling, implementation, and analysis has been used to increase knowledge of the underlying biology while achieving engineering goals. Recent advances in Systems Biology technologies have drastically improved the amount of information that can be collected in each iteration. As well, Synthetic Biology tools are melding modeling and molecular implementation. These advances promise to move microbial engineering from the iterative approach to a design-oriented paradigm, similar to electrical circuits and architectural design. Genome-scale metabolic models, new tools for controlling expression, and integrated -omics analysis are described as key contributors in moving the field toward Design-based Engineering.

Original languageEnglish (US)
Pages (from-to)255-262
Number of pages8
JournalCurrent Opinion in Microbiology
Volume13
Issue number3
DOIs
StatePublished - Jun 2010

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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