Toward manipulating serotonin signaling via the microbiota–gut–brain axis

Blake A. Everett, Peter Tran, Arthur Prindle

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

It is now well established in humans that there is a bidirectional pathway of communication between the central and enteric nervous systems in which members of the microbiome participate. This microbiota–gut–brain axis (MGBA) is crucial for normal development and physiology, and its dysregulation has been implicated in a range of neurological and intestinal disorders. Investigations into the mechanistic underpinnings of the MGBA have identified serotonin as a molecule of particular interest. In this review, we highlight recent advances toward understanding the role of endogenous serotonin in microbial communities, how microbial communities bidirectionally interact with host serotonin, and potential future engineering opportunities to leverage these novel mechanisms for biomedical applications.

Original languageEnglish (US)
Article number102826
JournalCurrent Opinion in Biotechnology
Volume78
DOIs
StatePublished - Dec 2022

Funding

This work was supported by the Burroughs Wellcome Fund ( 1015883.01 ), the David and Lucile Packard Foundation ( 2018-68055 ), the Army Research Office ( W911NF-19-1-0136 ), Pew Charitable Trusts ( 2019-A-06953 ), and the Immunology and Molecular Pathogenesis Training Program at Northwestern University . These funding sources had no involvement in the preparation of this article.

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology
  • Biomedical Engineering

Fingerprint

Dive into the research topics of 'Toward manipulating serotonin signaling via the microbiota–gut–brain axis'. Together they form a unique fingerprint.

Cite this