Toward polymeric anticancer drug cocktails from ring-opening metathesis polymerization [1]

Keith J. Watson; Donde R. Anderson; Son Binh T. Nguyen

doi:10.1021/ma001916t

Toward polymeric anticancer drug cocktails from ring-opening metathesis polymerization [1]

Keith J. Watson, Donde R. Anderson, Son Binh T. Nguyen^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Letter › peer-review

59 Scopus citations

Abstract

Anticancer drug cocktails were prepared using living ring-opening metathesis polymerization (ROMP). Three commercially available compounds with anticancer activity were modified using a norbornene group. Analysis showed that it was possible to polymerize the resulting multifunctional molecules by ruthenium carbene initiator. The polydispersity obtained in the living ROMP was found to be capable of controlling dosage in pharmacotherapy and pharmacokinetics.

Original language	English (US)
Pages (from-to)	3507-3509
Number of pages	3
Journal	Macromolecules
Volume	34
Issue number	11
DOIs	https://doi.org/10.1021/ma001916t
State	Published - May 22 2001

ASJC Scopus subject areas

Materials Chemistry
Polymers and Plastics
Inorganic Chemistry
Organic Chemistry

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10.1021/ma001916t

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title = "Toward polymeric anticancer drug cocktails from ring-opening metathesis polymerization [1]",

abstract = "Anticancer drug cocktails were prepared using living ring-opening metathesis polymerization (ROMP). Three commercially available compounds with anticancer activity were modified using a norbornene group. Analysis showed that it was possible to polymerize the resulting multifunctional molecules by ruthenium carbene initiator. The polydispersity obtained in the living ROMP was found to be capable of controlling dosage in pharmacotherapy and pharmacokinetics.",

author = "Watson, {Keith J.} and Anderson, {Donde R.} and Nguyen, {Son Binh T.}",

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AU - Nguyen, Son Binh T.

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N2 - Anticancer drug cocktails were prepared using living ring-opening metathesis polymerization (ROMP). Three commercially available compounds with anticancer activity were modified using a norbornene group. Analysis showed that it was possible to polymerize the resulting multifunctional molecules by ruthenium carbene initiator. The polydispersity obtained in the living ROMP was found to be capable of controlling dosage in pharmacotherapy and pharmacokinetics.

AB - Anticancer drug cocktails were prepared using living ring-opening metathesis polymerization (ROMP). Three commercially available compounds with anticancer activity were modified using a norbornene group. Analysis showed that it was possible to polymerize the resulting multifunctional molecules by ruthenium carbene initiator. The polydispersity obtained in the living ROMP was found to be capable of controlling dosage in pharmacotherapy and pharmacokinetics.

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Toward polymeric anticancer drug cocktails from ring-opening metathesis polymerization [1]

Abstract

ASJC Scopus subject areas

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