Toward the etiologies of congenital heart diseases

Andrew N. Pelech*, Ulrich Broeckel

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Congenital heart disease remains a significant cause of morbidity and mortality. In recent years, significant advances in molecular genetics, improved understanding of morphogenesis, recognition of specific patterning of abnormalities within and between species, and the impact of the Human Genome Project have accounted for these advances. Continued rapid developments in genomics and proteomics are anticipated. Epidemiologic investigations continue to be necessary to assess the influence of the environment on genetics. It is exciting to know that we are on the threshold of influencing the occurrence of congenital heart diseases.

Original languageEnglish (US)
Pages (from-to)825-844
Number of pages20
JournalClinics in Perinatology
Issue number4
StatePublished - Dec 2005
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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