Toward tolerance to human organ transplants: A few additional corollaries and questions

Joshua Miller*, James M. Mathew, Violet Esquenazi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Several component mechanisms of "central" (thymic) and "peripheral" tolerance in human organ transplant recipients are briefly discussed, in opposition to a more confined view limited to clonal depletion and exhaustion as proposed by Starzl (Transplantation 2004; 77(6): 926). Attention is directed to more than 40 years of experimental work in adult animal species dealing with immunoregulation. This work is in contradistinction to the simpler depletion/exhaustion explanation of Starzl (and Zinkernagel) regarding the potential of human organ transplant recipients to be significantly (or totally) withdrawn from continuous immunosuppression. Other observations are included touching on the roles of certain viral infections, the thymus, and the bone marrow in arriving at a state of "alloimmune homeostasis" in humans.

Original languageEnglish (US)
Pages (from-to)940-942
Number of pages3
JournalTransplantation
Volume77
Issue number6
DOIs
StatePublished - Mar 27 2004

ASJC Scopus subject areas

  • Transplantation

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