@article{9b3fe614182a480ca77728f38971ebb3,
title = "Towards Cell and Subtype Resolved Functional Organization: Mouse as a Model for the Cortical Control of Movement",
abstract = "Despite a long history of interrogation, the functional organization of motor cortex remains obscure. A major barrier has been the inability to measure and perturb activity with sufficient resolution to reveal clear functional elements within motor cortex and its associated circuits. Increasingly, the mouse has been employed as a model to facilitate application of contemporary approaches with the potential to surmount this barrier. In this brief essay, we consider these approaches and their use in the context of studies aimed at resolving the logic of motor cortical operation.",
keywords = "behavioral paradigm, cell types, corticospinal, motor control, motor cortex, motor learning",
author = "Warriner, {Claire L.} and Fageiry, {Samaher K.} and Carmona, {Lina M.} and Andrew Miri",
note = "Funding Information: This article was written in memoriam of Thomas Jessell. The last decade of research in the Jessell lab represented a transition from questions of neuronal development and circuit assembly in the spinal cord to those relating to the organization and function of motor circuits more broadly. Though this transition was at an early stage, his approach displayed the same clarity of thought and scientific rigor that was characteristic throughout his career. We would also like to thank Edera Daubert for illustrations. This work was supported by a National Institute of Health Brain Initiative U19 (C.L.W., S.K.F., L.M.C.), by a NIH - NINDS T32 Training Grant and F31 Predoctoral Award (C.L.W.), the Fulbright Science and Technology Scholars Program (S.K.F.), the Helen Hay Whitney Foundation (L.M.C.), a Searle Scholar Award, Sloan Research Fellowship , Whitehall Research Grant Award, and the Chicago Biomedical Consortium with support from the Searle Funds at the Chicago Community Trust (A.M.). Funding Information: This article was written in memoriam of Thomas Jessell. The last decade of research in the Jessell lab represented a transition from questions of neuronal development and circuit assembly in the spinal cord to those relating to the organization and function of motor circuits more broadly. Though this transition was at an early stage, his approach displayed the same clarity of thought and scientific rigor that was characteristic throughout his career. We would also like to thank Edera Daubert for illustrations. This work was supported by a National Institute of Health Brain Initiative U19 (C.L.W. S.K.F. L.M.C.), by a NIH-NINDS T32 Training Grant and F31 Predoctoral Award (C.L.W.), the Fulbright Science and Technology Scholars Program (S.K.F.), the Helen Hay Whitney Foundation (L.M.C.), a Searle Scholar Award, Sloan Research Fellowship, Whitehall Research Grant Award, and the Chicago Biomedical Consortium with support from the Searle Funds at the Chicago Community Trust (A.M.). Publisher Copyright: {\textcopyright} 2020 IBRO",
year = "2020",
month = dec,
day = "1",
doi = "10.1016/j.neuroscience.2020.07.054",
language = "English (US)",
volume = "450",
pages = "151--160",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Limited",
}