Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease

Kirsten L. Viola, James Sbarboro, Ruchi Sureka, Mrinmoy De, Maíra A. Bicca, Jane Wang, Shaleen Vasavada, Sreyesh Satpathy, Summer Wu, Hrushikesh Joshi, Pauline T. Velasco, Keith Macrenaris, E. Alex Waters, Chang Lu, Joseph Phan, Pascale Lacor, Pottumarthi Prasad, Vinayak P. Dravid, William L. Klein*

*Corresponding author for this work

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

One way to image the molecular pathology in Alzheimer's disease is by positron emission tomography using probes that target amyloid fibrils. However, these fibrils are not closely linked to the development of the disease. It is now thought that early-stage biomarkers that instigate memory loss are composed of Aβ oligomers. Here, we report a sensitive molecular magnetic resonance imaging contrast probe that is specific for Aβ oligomers. We attach oligomer-specific antibodies onto magnetic nanostructures and show that the complex is stable and binds to Aβ oligomers on cells and brain tissues to give a magnetic resonance imaging signal. When intranasally administered to an Alzheimer's disease mouse model, the probe readily reached hippocampal Aβ oligomers. In isolated samples of human brain tissue, we observed a magnetic resonance imaging signal that distinguished Alzheimer's disease from controls. Such nanostructures that target neurotoxic Aβ oligomers are potentially useful for evaluating the efficacy of new drugs and ultimately for early-stage Alzheimer's disease diagnosis and disease management.

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalNature nanotechnology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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  • Cite this

    Viola, K. L., Sbarboro, J., Sureka, R., De, M., Bicca, M. A., Wang, J., Vasavada, S., Satpathy, S., Wu, S., Joshi, H., Velasco, P. T., Macrenaris, K., Waters, E. A., Lu, C., Phan, J., Lacor, P., Prasad, P., Dravid, V. P., & Klein, W. L. (2015). Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease. Nature nanotechnology, 10(1), 91-98. https://doi.org/10.1038/nnano.2014.254