Towards non-invasive high-resolution 3D nano-tomography by ultrasonic scanning probe microscopy

Hossein J. Sharahi, Gajendra Shekhawat, Vinayak Dravid, Philip Egberts, Seonghwan Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nanoscale imaging techniques that can be used to visualize and characterize local aggregations of the embedded nanoparticulates with sufficient resolution have attracted a great deal of interest. Ultrasonic scanning probe microscopy (SPM) and its derivatives are nondestructive techniques that can be used to elucidate subsurface nanoscale features and mechanical properties. Although many different ultrasonic methods have been used for subsurface imaging, the mechanisms and crucial parameters associated with the contrast formation in subsurface imaging are still unclear. Here, the impact of mechanical properties of the nanoparticulates/matrix, size of the nanoparticulates, buried depth of the nanoparticulates, and the ultrasonic excitation frequency on the developed ultrasonic SPM images have been investigated. To verify our theoretical model, experimental measurements of scanning near-field ultrasound holography (SNFUH) have been recreated in our theoretical analysis to reveal comparable variations in phase contrast measured in SNFUH while scanning over the nanoparticulates embedded in bacteria.

Original languageEnglish (US)
Title of host publicationInternational Conference on Nano-Bio Sensing, Imaging, and Spectroscopy 2017
EditorsJaebum Choo, Seung-Han Park
PublisherSPIE
ISBN (Electronic)9781510610934
DOIs
StatePublished - Jan 1 2017
EventInternational Conference on Nano-Bio Sensing, Imaging, and Spectroscopy 2017 - Jeju, Korea, Republic of
Duration: Feb 22 2017Feb 24 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10324
ISSN (Print)1605-7422

Other

OtherInternational Conference on Nano-Bio Sensing, Imaging, and Spectroscopy 2017
CountryKorea, Republic of
CityJeju
Period2/22/172/24/17

Keywords

  • Ultrasonic scanning probe microscopy
  • bacteria
  • nano-tomography
  • nanoparticulates

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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