Towards quantitative assays with peptide chips: A surface engineering approach

Benjamin T. Houseman*, Milan Mrksich

*Corresponding author for this work

Research output: Contribution to journalReview article

74 Scopus citations

Abstract

The development of peptide and protein microarrays has created enormous opportunities in biomedical research. Current chip-based assays are well suited for identifying candidate protein or enzyme activities but still require conventional solution phase experiments to validate hits. Here, three surface-engineering strategies for microarray design are described and are illustrated in the development of a peptide chip for the quantitative analysis of kinase activity on solid support. These strategies promise to widen the application of microarrays by permitting the evaluation of hits in a chip-based format.

Original languageEnglish (US)
Pages (from-to)279-281
Number of pages3
JournalTrends in biotechnology
Volume20
Issue number7
DOIs
StatePublished - Jul 1 2002

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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