Toxicity From the Use of Niacin to Beat Urine Drug Screening

Manoj K. Mittal*, Todd Florin, Jeanmarie Perrone, João H. Delgado, Kevin C. Osterhoudt

*Corresponding author for this work

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Niacin (vitamin B3) is promoted for rapidly clearing the body of drugs of abuse, such as cocaine and cannabis, and is alleged to interfere with urine drug screening. We present 4 cases of such novel use associated with significant adverse effects. Two cases had isolated skin manifestations, whereas the other 2 presented with life-threatening manifestations, including nausea, vomiting, dizziness, hepatotoxicity, metabolic acidosis, and hypoglycemia evolving into hyperglycemia. One patient also had profound neutrophilia and QTC-interval prolongation. All patients improved after cessation of the drug use and supportive treatment. Health care providers should be aware of these potential adverse effects of niacin and of the misguided use of this vitamin by patients seeking to interfere with urine drug screening.

Original languageEnglish (US)
Pages (from-to)587-590
Number of pages4
JournalAnnals of Emergency Medicine
Volume50
Issue number5
DOIs
StatePublished - Nov 1 2007

Fingerprint

Preclinical Drug Evaluations
Niacin
Urine
Skin Manifestations
Niacinamide
Dizziness
Street Drugs
Cannabis
Acidosis
Cocaine
Hypoglycemia
Vitamins
Hyperglycemia
Health Personnel
Nausea
Vomiting
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Mittal, Manoj K. ; Florin, Todd ; Perrone, Jeanmarie ; Delgado, João H. ; Osterhoudt, Kevin C. / Toxicity From the Use of Niacin to Beat Urine Drug Screening. In: Annals of Emergency Medicine. 2007 ; Vol. 50, No. 5. pp. 587-590.
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Toxicity From the Use of Niacin to Beat Urine Drug Screening. / Mittal, Manoj K.; Florin, Todd; Perrone, Jeanmarie; Delgado, João H.; Osterhoudt, Kevin C.

In: Annals of Emergency Medicine, Vol. 50, No. 5, 01.11.2007, p. 587-590.

Research output: Contribution to journalArticle

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