Tracing Neural Connections of Human Brain with Selective Silver Impregnation: Observations on Geniculocalcarine, Spinothalamic, and Entorhinal Pathways

M. Marsel Mesulam*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

In selected human brains, it is possible to study the efferent connections of a damaged site with the suppressive silver impregnation techniques described by Nauta and Gygax.1 Autopsy specimens with circumscribed lesions of recent origin (one to five weeks before death) are suitable. However, the large size of the human brain and the lack of perfusion with fixative necessitates modifications in the methodology used on experimental animals. With these modifications, it has been possible to trace details of the spinothalamic tract, the geniculocalcarine pathway, and a projection into the entorhinal area in autopsied human brains. More frequent use of this methodology may substantially increase the information that is currently available on the neuronal connections of the human brain.

Original languageEnglish (US)
Pages (from-to)814-818
Number of pages5
JournalArchives of Neurology
Volume36
Issue number13
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

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