Trans-middle temporal gyrus selective amygdalohippocampectomy for medically intractable mesial temporal lobe epilepsy in adults: Seizure response rates, complications, and neuropsychological outcomes

S. Kathleen Bandt*, Nicole Werner, Jennifer Dines, Samiya Rashid, Lawrence N. Eisenman, R. Edward Hogan, Eric C. Leuthardt, Joshua Dowling

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: Selective amygdalohippocampectomy (AHC) has evolved to encompass a variety of techniques to resect the mesial temporal lobe. To date, there have been few large-scale evaluations of trans-middle temporal gyrus selective AHC. The authors examine a large series of patients who have undergone the trans-middle temporal gyrus AHC and assess its clinical and neuropsychological impact. Methods: A series of 76 adult patients underwent selective AHC via the trans-middle temporal gyrus approach over a 10-year period, 19 of whom underwent pre- and postoperative neuropsychological evaluations. Results: Favorable seizure response rates were achieved (92% Engel class I or II), with very low surgical morbidity and no mortality. Postoperative neuropsychological assessment revealed a decline in verbal memory for the left AHC group. No postoperative memory decline was identified for the right AHC group, but rather some improvements were noted within this group. Conclusions: The trans-middle temporal gyrus selective AHC is a safe and effective choice for management of medically refractory epilepsy in adults.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalEpilepsy and Behavior
Volume28
Issue number1
DOIs
StatePublished - Jul 1 2013

Fingerprint

Temporal Lobe Epilepsy
Temporal Lobe
Seizures
Epilepsy
Morbidity
Mortality

Keywords

  • Epilepsy
  • Neuropsychological outcomes
  • Selective amygdalohippocampectomy
  • Temporal stem

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Cite this

Bandt, S. Kathleen ; Werner, Nicole ; Dines, Jennifer ; Rashid, Samiya ; Eisenman, Lawrence N. ; Hogan, R. Edward ; Leuthardt, Eric C. ; Dowling, Joshua. / Trans-middle temporal gyrus selective amygdalohippocampectomy for medically intractable mesial temporal lobe epilepsy in adults : Seizure response rates, complications, and neuropsychological outcomes. In: Epilepsy and Behavior. 2013 ; Vol. 28, No. 1. pp. 17-21.
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Trans-middle temporal gyrus selective amygdalohippocampectomy for medically intractable mesial temporal lobe epilepsy in adults : Seizure response rates, complications, and neuropsychological outcomes. / Bandt, S. Kathleen; Werner, Nicole; Dines, Jennifer; Rashid, Samiya; Eisenman, Lawrence N.; Hogan, R. Edward; Leuthardt, Eric C.; Dowling, Joshua.

In: Epilepsy and Behavior, Vol. 28, No. 1, 01.07.2013, p. 17-21.

Research output: Contribution to journalArticle

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AU - Bandt, S. Kathleen

AU - Werner, Nicole

AU - Dines, Jennifer

AU - Rashid, Samiya

AU - Eisenman, Lawrence N.

AU - Hogan, R. Edward

AU - Leuthardt, Eric C.

AU - Dowling, Joshua

PY - 2013/7/1

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N2 - Objective: Selective amygdalohippocampectomy (AHC) has evolved to encompass a variety of techniques to resect the mesial temporal lobe. To date, there have been few large-scale evaluations of trans-middle temporal gyrus selective AHC. The authors examine a large series of patients who have undergone the trans-middle temporal gyrus AHC and assess its clinical and neuropsychological impact. Methods: A series of 76 adult patients underwent selective AHC via the trans-middle temporal gyrus approach over a 10-year period, 19 of whom underwent pre- and postoperative neuropsychological evaluations. Results: Favorable seizure response rates were achieved (92% Engel class I or II), with very low surgical morbidity and no mortality. Postoperative neuropsychological assessment revealed a decline in verbal memory for the left AHC group. No postoperative memory decline was identified for the right AHC group, but rather some improvements were noted within this group. Conclusions: The trans-middle temporal gyrus selective AHC is a safe and effective choice for management of medically refractory epilepsy in adults.

AB - Objective: Selective amygdalohippocampectomy (AHC) has evolved to encompass a variety of techniques to resect the mesial temporal lobe. To date, there have been few large-scale evaluations of trans-middle temporal gyrus selective AHC. The authors examine a large series of patients who have undergone the trans-middle temporal gyrus AHC and assess its clinical and neuropsychological impact. Methods: A series of 76 adult patients underwent selective AHC via the trans-middle temporal gyrus approach over a 10-year period, 19 of whom underwent pre- and postoperative neuropsychological evaluations. Results: Favorable seizure response rates were achieved (92% Engel class I or II), with very low surgical morbidity and no mortality. Postoperative neuropsychological assessment revealed a decline in verbal memory for the left AHC group. No postoperative memory decline was identified for the right AHC group, but rather some improvements were noted within this group. Conclusions: The trans-middle temporal gyrus selective AHC is a safe and effective choice for management of medically refractory epilepsy in adults.

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