Trans-middle temporal gyrus selective amygdalohippocampectomy for medically intractable mesial temporal lobe epilepsy in adults: Seizure response rates, complications, and neuropsychological outcomes

S. Kathleen Bandt*, Nicole Werner, Jennifer Dines, Samiya Rashid, Lawrence N. Eisenman, R. Edward Hogan, Eric C. Leuthardt, Joshua Dowling

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations


Objective: Selective amygdalohippocampectomy (AHC) has evolved to encompass a variety of techniques to resect the mesial temporal lobe. To date, there have been few large-scale evaluations of trans-middle temporal gyrus selective AHC. The authors examine a large series of patients who have undergone the trans-middle temporal gyrus AHC and assess its clinical and neuropsychological impact. Methods: A series of 76 adult patients underwent selective AHC via the trans-middle temporal gyrus approach over a 10-year period, 19 of whom underwent pre- and postoperative neuropsychological evaluations. Results: Favorable seizure response rates were achieved (92% Engel class I or II), with very low surgical morbidity and no mortality. Postoperative neuropsychological assessment revealed a decline in verbal memory for the left AHC group. No postoperative memory decline was identified for the right AHC group, but rather some improvements were noted within this group. Conclusions: The trans-middle temporal gyrus selective AHC is a safe and effective choice for management of medically refractory epilepsy in adults.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalEpilepsy and Behavior
Issue number1
StatePublished - Jul 1 2013



  • Epilepsy
  • Neuropsychological outcomes
  • Selective amygdalohippocampectomy
  • Temporal stem

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

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