TY - JOUR
T1 - Transabdominal chorionic villus sampling for first-trimester prenatal diagnosis
AU - Elias, Sherman
AU - Simpson, Joe Leigh
AU - Shulman, Lee P.
AU - Emerson, Donald
AU - Tharapel, Avirachan
AU - Seely, Linda
N1 - Funding Information:
From the Dlv!Slon of ReproductIVe GenetiCS, Department of Obstetncs and Gynecology," the Department of RadIOlogy.' and the Section of Genetic;, Department of Pedwtncs: The Univem(v of Tennessee, Memplw.. Supported In part by NatIOnal Instztutes of Health Grant A123479, Contract N01-HD-8-2904, the March of Dimes Birth Defects Foundation, and the U.S. Agency for InternatIOnal Development. Presented at the Seventh Annual Meetmg of the Amencan Gyneco- 10f51cal and Obstetmal Society, Napa, California, September 8-10, 1988 Reprint requests. Sherman Eltas, MD, DIVISIOn of Reproductive Ge-netlCl, Department of Ob,tetries and Gynecology, 853 jefferson Ave .. Mempht" TN 38163.
PY - 1989/4
Y1 - 1989/4
N2 - We report here our technique and initial experience with transabdominal chorionic villus sampling for first-trimester prenatal diagnosis at the University of Tennessee, Memphis. Eighty-seven patients underwent transabdominal chorionic villus sampling between 9 and 12 menstrual weeks of pregnancy. Sufficient chorionic villi (≥5 mg) were obtained from 83 of the 87 patients (95.4%); in 73 (88%) of the 83 successful samplings only a single needle passage was required. In one case a 47,XX, +21 complement was diagnosed; the patient elected to terminate the pregnancy and the diagnosis was confirmed in the abortus. In a second case a 46,XX,rcp(15;21)(p11;q21) woman had a fetus who also had the same balanced translocation. In a third case nonmosaic 47,XX, +16 was detected in both direct preparations of cytotrophoblast cells and cultured mesenchymal core cells. Amniocentesis performed at 15 weeks showed a normal 46,XX complement. The pregnancy continued, and the patient was delivered at term of a healthy female infant. Two spontaneous fetal losses occurred in this series, and one woman underwent an elective abortion after receiving the results of a 46,XX complement. To date, 39 of the women have been delivered and all infants are doing well; the remaining 44 pregnancies are continuing uneventfully. We conclude that transabdominal chorionic villus sampling can be a useful altermative to transcervical chorionic villus sampling, particularly when transcervical sampling is contraindicated (e.g., active genital herpes) or where the transcervical approach would be technically difficult.
AB - We report here our technique and initial experience with transabdominal chorionic villus sampling for first-trimester prenatal diagnosis at the University of Tennessee, Memphis. Eighty-seven patients underwent transabdominal chorionic villus sampling between 9 and 12 menstrual weeks of pregnancy. Sufficient chorionic villi (≥5 mg) were obtained from 83 of the 87 patients (95.4%); in 73 (88%) of the 83 successful samplings only a single needle passage was required. In one case a 47,XX, +21 complement was diagnosed; the patient elected to terminate the pregnancy and the diagnosis was confirmed in the abortus. In a second case a 46,XX,rcp(15;21)(p11;q21) woman had a fetus who also had the same balanced translocation. In a third case nonmosaic 47,XX, +16 was detected in both direct preparations of cytotrophoblast cells and cultured mesenchymal core cells. Amniocentesis performed at 15 weeks showed a normal 46,XX complement. The pregnancy continued, and the patient was delivered at term of a healthy female infant. Two spontaneous fetal losses occurred in this series, and one woman underwent an elective abortion after receiving the results of a 46,XX complement. To date, 39 of the women have been delivered and all infants are doing well; the remaining 44 pregnancies are continuing uneventfully. We conclude that transabdominal chorionic villus sampling can be a useful altermative to transcervical chorionic villus sampling, particularly when transcervical sampling is contraindicated (e.g., active genital herpes) or where the transcervical approach would be technically difficult.
KW - Transabdominal chorionic villus sampling
KW - prenatal diagnosis
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U2 - 10.1016/0002-9378(89)90304-9
DO - 10.1016/0002-9378(89)90304-9
M3 - Article
C2 - 2712119
AN - SCOPUS:0024516228
VL - 160
SP - 879
EP - 886
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 4
ER -