Transcatheter arterial chemo-embolization for humoral hypercalcemia of hepatocellular carcinoma

Koyasu Suzuki*, Norio Kono, Akira Ono, Yasufumi Osuga, Hiroaki Kiyokawa, Ikuo Mineo, Yukihiko Matsuda, Shio Miyoshi, Sumio Kawata, Yuzo Minami, Kaname Moriwaki, Seiichiro Tarui

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations


A 50-year-old male with unresectable hepatocellular carcinoma (HCC) had a hypercalcemic crisis with a serum calcium concentration of 7.8 mEq/ℓ, without any evidence for bone metastases or parathyroid lesions. The hypercalcemia was thought to be due to increased renal reabsorption of calcium and increased bone resorption, which was probably caused by humoral factors derived from the HCC, some being parathyroid hormone-like factors. Since conservative therapy for hypercalcemia was not sufficiently effective and was accompanied by progressive exacerbation of ascites and leg edema, transcatheter arterial chemo-embolization (TACE) was performed. On the following day, serum calcium concentration decreased from 6.3 mEq/ℓ to the normal range, although serum α-fetoprotein levels decreased only slightly. Thereafter hypercalcemia did not develop for about 4 weeks. The results demonstrated that TACE can be effective for humoral hypercalcemia of HCC.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalGastroenterologia Japonica
Issue number1
StatePublished - Feb 1 1988


  • Hepatocellular carcinoma
  • Humoral hypercalcemia of malignancy
  • PTH-like factors
  • Transcatheter arterial chemo-embolization

ASJC Scopus subject areas

  • Gastroenterology

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    Suzuki, K., Kono, N., Ono, A., Osuga, Y., Kiyokawa, H., Mineo, I., Matsuda, Y., Miyoshi, S., Kawata, S., Minami, Y., Moriwaki, K., & Tarui, S. (1988). Transcatheter arterial chemo-embolization for humoral hypercalcemia of hepatocellular carcinoma. Gastroenterologia Japonica, 23(1), 29-36.