Transcranial Doppler Identification of Neurologic Injury during Pediatric Extracorporeal Membrane Oxygenation Therapy

Jay F. Rilinger, Craig Martin Smith, Raye-Ann O de Regnier, Joshua L Goldstein, Michele G. Mills, Marleta Reynolds, Carl L Backer, Delilah M. Burrowes, Priya Mehta, Juan Piantino, Mark S. Wainwright*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background We used transcranial Doppler to examine changes in cerebral blood flow velocity in children treated with extracorporeal membrane oxygenation. We examined the association between those changes and radiologic, electroencephalographic, and clinical evidence of neurologic injury. Methods This was a retrospective review and prospective observational study of patients 18 years old and younger at a single university children's hospital. Transcranial Doppler studies were obtained every other day during the first 7 days of extracorporeal membrane oxygenation, and 1 additional study following decannulation, in conjunction with serial neurologic examinations, brain imaging, and 6- to 12-month follow-up. Results The study included 27 patients, the majority (26) receiving veno-arterial extracorporeal membrane oxygenation. Transcranial Doppler velocities during extracorporeal membrane oxygenation were significantly lower than published values for age-matched healthy and critically ill children across different cerebral arteries. Neonates younger than 10 days had higher velocities than expected. Blood flow velocity increased after extracorporeal membrane oxygenation decannulation and was comparable with age-matched critically ill children. There was no significant association between velocity measurements of individual arteries and acute neurologic injury as defined by either abnormal neurologic examination, seizures during admission, or poor pediatric cerebral performance category. However, case analysis identified several patients with regional and global increases in velocities that corresponded to neurologic injury including stroke and seizures. Conclusions Cerebral blood flow velocities during extracorporeal membrane oxygenation deviate from age-specific normal values in all major cerebral vessels and across different age groups. Global or regional elevations and asymmetries in flow velocity may suggest impending neurologic injury.

Original languageEnglish (US)
Pages (from-to)2336-2345
Number of pages10
JournalJournal of Stroke and Cerebrovascular Diseases
Volume26
Issue number10
DOIs
StatePublished - Oct 1 2017

Fingerprint

Nervous System Trauma
Extracorporeal Membrane Oxygenation
Pediatrics
Blood Flow Velocity
Cerebrovascular Circulation
Neurologic Examination
Critical Illness
Seizures
Therapeutics
Cerebral Arteries
Neuroimaging
Observational Studies
Reference Values
Arteries
Age Groups
Stroke
Newborn Infant
Prospective Studies

Keywords

  • Cerebral blood flow
  • ECMO
  • pediatric
  • transcranial Doppler

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

@article{4e2255f94681456685fb4da8233e0cf2,
title = "Transcranial Doppler Identification of Neurologic Injury during Pediatric Extracorporeal Membrane Oxygenation Therapy",
abstract = "Background We used transcranial Doppler to examine changes in cerebral blood flow velocity in children treated with extracorporeal membrane oxygenation. We examined the association between those changes and radiologic, electroencephalographic, and clinical evidence of neurologic injury. Methods This was a retrospective review and prospective observational study of patients 18 years old and younger at a single university children's hospital. Transcranial Doppler studies were obtained every other day during the first 7 days of extracorporeal membrane oxygenation, and 1 additional study following decannulation, in conjunction with serial neurologic examinations, brain imaging, and 6- to 12-month follow-up. Results The study included 27 patients, the majority (26) receiving veno-arterial extracorporeal membrane oxygenation. Transcranial Doppler velocities during extracorporeal membrane oxygenation were significantly lower than published values for age-matched healthy and critically ill children across different cerebral arteries. Neonates younger than 10 days had higher velocities than expected. Blood flow velocity increased after extracorporeal membrane oxygenation decannulation and was comparable with age-matched critically ill children. There was no significant association between velocity measurements of individual arteries and acute neurologic injury as defined by either abnormal neurologic examination, seizures during admission, or poor pediatric cerebral performance category. However, case analysis identified several patients with regional and global increases in velocities that corresponded to neurologic injury including stroke and seizures. Conclusions Cerebral blood flow velocities during extracorporeal membrane oxygenation deviate from age-specific normal values in all major cerebral vessels and across different age groups. Global or regional elevations and asymmetries in flow velocity may suggest impending neurologic injury.",
keywords = "Cerebral blood flow, ECMO, pediatric, transcranial Doppler",
author = "Rilinger, {Jay F.} and Smith, {Craig Martin} and {de Regnier}, {Raye-Ann O} and Goldstein, {Joshua L} and Mills, {Michele G.} and Marleta Reynolds and Backer, {Carl L} and Burrowes, {Delilah M.} and Priya Mehta and Juan Piantino and Wainwright, {Mark S.}",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.jstrokecerebrovasdis.2017.05.022",
language = "English (US)",
volume = "26",
pages = "2336--2345",
journal = "Journal of Stroke and Cerebrovascular Diseases",
issn = "1052-3057",
publisher = "W.B. Saunders Ltd",
number = "10",

}

Transcranial Doppler Identification of Neurologic Injury during Pediatric Extracorporeal Membrane Oxygenation Therapy. / Rilinger, Jay F.; Smith, Craig Martin; de Regnier, Raye-Ann O; Goldstein, Joshua L; Mills, Michele G.; Reynolds, Marleta; Backer, Carl L; Burrowes, Delilah M.; Mehta, Priya; Piantino, Juan; Wainwright, Mark S.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 26, No. 10, 01.10.2017, p. 2336-2345.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Transcranial Doppler Identification of Neurologic Injury during Pediatric Extracorporeal Membrane Oxygenation Therapy

AU - Rilinger, Jay F.

AU - Smith, Craig Martin

AU - de Regnier, Raye-Ann O

AU - Goldstein, Joshua L

AU - Mills, Michele G.

AU - Reynolds, Marleta

AU - Backer, Carl L

AU - Burrowes, Delilah M.

AU - Mehta, Priya

AU - Piantino, Juan

AU - Wainwright, Mark S.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background We used transcranial Doppler to examine changes in cerebral blood flow velocity in children treated with extracorporeal membrane oxygenation. We examined the association between those changes and radiologic, electroencephalographic, and clinical evidence of neurologic injury. Methods This was a retrospective review and prospective observational study of patients 18 years old and younger at a single university children's hospital. Transcranial Doppler studies were obtained every other day during the first 7 days of extracorporeal membrane oxygenation, and 1 additional study following decannulation, in conjunction with serial neurologic examinations, brain imaging, and 6- to 12-month follow-up. Results The study included 27 patients, the majority (26) receiving veno-arterial extracorporeal membrane oxygenation. Transcranial Doppler velocities during extracorporeal membrane oxygenation were significantly lower than published values for age-matched healthy and critically ill children across different cerebral arteries. Neonates younger than 10 days had higher velocities than expected. Blood flow velocity increased after extracorporeal membrane oxygenation decannulation and was comparable with age-matched critically ill children. There was no significant association between velocity measurements of individual arteries and acute neurologic injury as defined by either abnormal neurologic examination, seizures during admission, or poor pediatric cerebral performance category. However, case analysis identified several patients with regional and global increases in velocities that corresponded to neurologic injury including stroke and seizures. Conclusions Cerebral blood flow velocities during extracorporeal membrane oxygenation deviate from age-specific normal values in all major cerebral vessels and across different age groups. Global or regional elevations and asymmetries in flow velocity may suggest impending neurologic injury.

AB - Background We used transcranial Doppler to examine changes in cerebral blood flow velocity in children treated with extracorporeal membrane oxygenation. We examined the association between those changes and radiologic, electroencephalographic, and clinical evidence of neurologic injury. Methods This was a retrospective review and prospective observational study of patients 18 years old and younger at a single university children's hospital. Transcranial Doppler studies were obtained every other day during the first 7 days of extracorporeal membrane oxygenation, and 1 additional study following decannulation, in conjunction with serial neurologic examinations, brain imaging, and 6- to 12-month follow-up. Results The study included 27 patients, the majority (26) receiving veno-arterial extracorporeal membrane oxygenation. Transcranial Doppler velocities during extracorporeal membrane oxygenation were significantly lower than published values for age-matched healthy and critically ill children across different cerebral arteries. Neonates younger than 10 days had higher velocities than expected. Blood flow velocity increased after extracorporeal membrane oxygenation decannulation and was comparable with age-matched critically ill children. There was no significant association between velocity measurements of individual arteries and acute neurologic injury as defined by either abnormal neurologic examination, seizures during admission, or poor pediatric cerebral performance category. However, case analysis identified several patients with regional and global increases in velocities that corresponded to neurologic injury including stroke and seizures. Conclusions Cerebral blood flow velocities during extracorporeal membrane oxygenation deviate from age-specific normal values in all major cerebral vessels and across different age groups. Global or regional elevations and asymmetries in flow velocity may suggest impending neurologic injury.

KW - Cerebral blood flow

KW - ECMO

KW - pediatric

KW - transcranial Doppler

UR - http://www.scopus.com/inward/record.url?scp=85020124938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020124938&partnerID=8YFLogxK

U2 - 10.1016/j.jstrokecerebrovasdis.2017.05.022

DO - 10.1016/j.jstrokecerebrovasdis.2017.05.022

M3 - Article

C2 - 28583819

AN - SCOPUS:85020124938

VL - 26

SP - 2336

EP - 2345

JO - Journal of Stroke and Cerebrovascular Diseases

JF - Journal of Stroke and Cerebrovascular Diseases

SN - 1052-3057

IS - 10

ER -