Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory

Arantzazu San Agustín*, David Crevillén, Vanesa Soto-León, Juan C. Moreno, Antonio Oliviero, José L. Pons

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The hippocampus is a fundamental cortical structure in the memory process of encoding, retaining, and recalling information. Transcranial Magnetic Stimulation (TMS) following a Paired Associative Stimulation (PAS) enhances nervous system excitability and promotes cortical plasticity mechanisms by synchronizing two stimuli in the same neural pathway. However, PAS has not been shown to improve memorization capacity yet. Here, we present an innovative protocol stemming from the PAS paradigm, which combines single-pulse TMS to the hippocampus with endogenous hippocampal activity during a working memory (WM) task. 96 volunteers were randomized across one experimental group and three parallel groups (motor cortex stimulation, sham stimulation, and no stimulation) in a single session. This combined-stimuli configuration resulted in an increased memorization capacity in theWMtask, which was dependent on the stimulated brain location and subjects' basal memory performance. These results are potentially significant for clinical research on memory dysfunction and its related neurological disorders. Future research on paired associative or combined stimulation is required to unveil stimulation-derived neural mechanisms that enhance the ability to memorize.

Original languageEnglish (US)
Article numbere0295413
JournalPloS one
Volume18
Issue number12 December
DOIs
StatePublished - Dec 2023

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'Transcranial magnetic stimulation combined with endogenous human hippocampal and motor cortical activity enhances memory'. Together they form a unique fingerprint.

Cite this