Transcription factor networks in erythroid cell and megakaryocyte development

Louis C. Doré, John D. Crispino*

*Corresponding author for this work

Research output: Contribution to journalReview article

117 Scopus citations

Abstract

Erythroid cells and megakaryocytes are derived from a common precursor, the megakaryocyte-erythroid progenitor. Although these 2 closely related hematopoietic cell types share many transcription factors, there are several key differences in their regulatory networks that lead to differential gene expression downstream of the megakaryocyte-erythroid progenitor. With the advent of next-generation sequencing and our ability to precisely define transcription factor chromatin occupancy in vivo on a global scale, we are much closer to understanding how these 2 lineages are specified and in general how transcription factor complexes govern hematopoiesis.

Original languageEnglish (US)
Pages (from-to)231-239
Number of pages9
JournalBlood
Volume118
Issue number2
DOIs
StatePublished - Jul 14 2011

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ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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