Transcription factors and ABC transporters: from pleiotropic drug resistance to cellular signaling in yeast

Evan R. Buechel, Heather W. Pinkett*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Budding yeast Saccharomyces cerevisiae survives in microenvironments utilizing networks of regulators and ATP-binding cassette (ABC) transporters to circumvent toxins and a variety of drugs. Our understanding of transcriptional regulation of ABC transporters in yeast is mainly derived from the study of multidrug resistance protein networks. Over the past two decades, this research has not only expanded the role of transcriptional regulators in pleiotropic drug resistance (PDR) but evolved to include the role that regulators play in cellular signaling and environmental adaptation. Inspection of the gene networks of the transcriptional regulators and characterization of the ABC transporters has clarified that they also contribute to environmental adaptation by controlling plasma membrane composition, toxic-metal sequestration, and oxidative stress adaptation. Additionally, ABC transporters and their regulators appear to be involved in cellular signaling for adaptation of S. cerevisiae populations to nutrient availability. In this review, we summarize the current understanding of the S. cerevisiae transcriptional regulatory networks and highlight recent work in other notable fungal organisms, underlining the expansion of the study of these gene networks across the kingdom fungi.

Original languageEnglish (US)
Pages (from-to)3943-3964
Number of pages22
JournalFEBS Letters
Issue number23
StatePublished - Dec 2020


  • ABC transporters
  • cellular detoxification
  • cellular signaling
  • cellular stress
  • drug resistance
  • gene regulation
  • lipid transport
  • pleiotropic drug resistance
  • transcription factors
  • yeast

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biophysics
  • Structural Biology
  • Biochemistry
  • Cell Biology


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