Transcriptional control of effector and memory CD8+ T cell differentiation

Susan M. Kaech*, Weiguo Cui

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

947 Scopus citations


During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8+ T cells have started to be characterized, and this Review discusses the major advances in these areas.

Original languageEnglish (US)
Pages (from-to)749-761
Number of pages13
JournalNature Reviews Immunology
Issue number11
StatePublished - Nov 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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