Transcriptional control of effector and memory CD8+ T cell differentiation

Susan M. Kaech; Weiguo Cui

doi:10.1038/nri3307

Transcriptional control of effector and memory CD8⁺ T cell differentiation

Susan M. Kaech^*, Weiguo Cui

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Review article › peer-review

1124 Scopus citations

Abstract

During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8⁺ T cells have started to be characterized, and this Review discusses the major advances in these areas.

Original language	English (US)
Pages (from-to)	749-761
Number of pages	13
Journal	Nature Reviews Immunology
Volume	12
Issue number	11
DOIs	https://doi.org/10.1038/nri3307
State	Published - Nov 2012

Funding

We thank the members of the Kaech laboratory for helpful com‑ ments and discussions. This work was supported by grants to S.M.K. from the US National Institutes of Health (grants R01AI074699, RO1AI066232, R21AI097767 and R21AI081150) and from the Howard Hughes Medical Institute.

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1038/nri3307

Cite this

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abstract = "During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8+ T cells have started to be characterized, and this Review discusses the major advances in these areas.",

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