TY - JOUR
T1 - Transcriptional control of effector and memory CD8+ T cell differentiation
AU - Kaech, Susan M.
AU - Cui, Weiguo
N1 - Funding Information:
We thank the members of the Kaech laboratory for helpful com‑ ments and discussions. This work was supported by grants to S.M.K. from the US National Institutes of Health (grants R01AI074699, RO1AI066232, R21AI097767 and R21AI081150) and from the Howard Hughes Medical Institute.
PY - 2012/11
Y1 - 2012/11
N2 - During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8+ T cells have started to be characterized, and this Review discusses the major advances in these areas.
AB - During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8+ T cells have started to be characterized, and this Review discusses the major advances in these areas.
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U2 - 10.1038/nri3307
DO - 10.1038/nri3307
M3 - Review article
C2 - 23080391
AN - SCOPUS:84867896903
SN - 1474-1733
VL - 12
SP - 749
EP - 761
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 11
ER -