Transcriptional coregulators: Fine-tuning metabolism

Laurent Mouchiroud, Lillian J. Eichner, Reuben J. Shaw*, Johan Auwerx

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations


Metabolic homeostasis requires that cellular energy levels are adapted to environmental cues. This adaptation is largely regulated at the transcriptional level, through the interaction between transcription factors, coregulators, and the basal transcriptional machinery. Coregulators, which function as both metabolic sensors and transcriptional effectors, are ideally positioned to synchronize metabolic pathways to environmental stimuli. The balance between inhibitory actions of corepressors and stimulatory effects of coactivators enables the fine-tuning of metabolic processes. This tight regulation opens therapeutic opportunities to manage metabolic dysfunction by directing the activity of cofactors toward specific transcription factors, pathways, or cells/tissues, thereby restoring whole-body metabolic homeostasis.

Original languageEnglish (US)
Pages (from-to)26-40
Number of pages15
JournalCell Metabolism
Issue number1
StatePublished - Jul 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Physiology
  • Cell Biology


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