Transcriptional elongation by RNA polymerase II and histone methylation

Mark Gerber, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalShort survey

134 Citations (Scopus)

Abstract

mRNA synthesis in eukaryotic organisms is a key biological process that is regulated at multiple levels. From the covalent modifications of chromatin by a number of chromatin remodeling complexes during the initiation and activation steps of transcription to the processing of mRNA transcripts, a very large consortium of proteins and multiprotein complexes is critical for gene expression by RNA polymerase II. The list of proteins essential for the successful synthesis of mRNA continues to grow at a rapid pace. Recent advances in this area of research have been focused on transcription through chromatin. In this article, we will review the recent literature linking the key biochemical process of transcriptional elongation by RNA polymerase II to histone methylation by COMPASS, Dot1p, and Set2 methyltransferases.

Original languageEnglish (US)
Pages (from-to)26303-26306
Number of pages4
JournalJournal of Biological Chemistry
Volume278
Issue number29
DOIs
StatePublished - Jul 18 2003

Fingerprint

Methylation
RNA Polymerase II
Histones
Chromatin
Elongation
Transcription
Messenger RNA
Biochemical Phenomena
Biological Phenomena
Multiprotein Complexes
Chromatin Assembly and Disassembly
Methyltransferases
Gene expression
Transcriptional Activation
Proteins
Chemical activation
Gene Expression
Processing
Research

ASJC Scopus subject areas

  • Biochemistry

Cite this

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title = "Transcriptional elongation by RNA polymerase II and histone methylation",
abstract = "mRNA synthesis in eukaryotic organisms is a key biological process that is regulated at multiple levels. From the covalent modifications of chromatin by a number of chromatin remodeling complexes during the initiation and activation steps of transcription to the processing of mRNA transcripts, a very large consortium of proteins and multiprotein complexes is critical for gene expression by RNA polymerase II. The list of proteins essential for the successful synthesis of mRNA continues to grow at a rapid pace. Recent advances in this area of research have been focused on transcription through chromatin. In this article, we will review the recent literature linking the key biochemical process of transcriptional elongation by RNA polymerase II to histone methylation by COMPASS, Dot1p, and Set2 methyltransferases.",
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Transcriptional elongation by RNA polymerase II and histone methylation. / Gerber, Mark; Shilatifard, Ali.

In: Journal of Biological Chemistry, Vol. 278, No. 29, 18.07.2003, p. 26303-26306.

Research output: Contribution to journalShort survey

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AU - Shilatifard, Ali

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