Transcriptional elongation checkpoint control in development and disease

Edwin Smith, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalReview article

46 Scopus citations

Abstract

Transcriptional elongation control by RNA polymerase II and its associated factors has taken center stage as a process essential for the regulation of gene expression throughout development. In this review, we analyze recent findings on the identification of factors functioning in the regulation of the transcriptional elongation checkpoint control (TECC) stage of gene expression and how the factors' misregulation is associated with disease pathogenesis, including cancer.

Original languageEnglish (US)
Pages (from-to)1079-1088
Number of pages10
JournalGenes and Development
Volume27
Issue number10
DOIs
StatePublished - May 15 2013

Keywords

  • Cancer
  • Chromatin
  • Elongation
  • RNA polymerase II
  • Transcription

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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