Transcriptional elongation checkpoint control in development and disease

Edwin Smith; Ali Shilatifard

doi:10.1101/gad.215137.113

Transcriptional elongation checkpoint control in development and disease

Edwin Smith, Ali Shilatifard^*

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

Transcriptional elongation control by RNA polymerase II and its associated factors has taken center stage as a process essential for the regulation of gene expression throughout development. In this review, we analyze recent findings on the identification of factors functioning in the regulation of the transcriptional elongation checkpoint control (TECC) stage of gene expression and how the factors' misregulation is associated with disease pathogenesis, including cancer.

Original language	English (US)
Pages (from-to)	1079-1088
Number of pages	10
Journal	Genes and Development
Volume	27
Issue number	10
DOIs	https://doi.org/10.1101/gad.215137.113
State	Published - May 15 2013

Keywords

Cancer
Chromatin
Elongation
RNA polymerase II
Transcription

ASJC Scopus subject areas

Genetics
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1101/gad.215137.113

Cite this

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abstract = "Transcriptional elongation control by RNA polymerase II and its associated factors has taken center stage as a process essential for the regulation of gene expression throughout development. In this review, we analyze recent findings on the identification of factors functioning in the regulation of the transcriptional elongation checkpoint control (TECC) stage of gene expression and how the factors' misregulation is associated with disease pathogenesis, including cancer.",

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AB - Transcriptional elongation control by RNA polymerase II and its associated factors has taken center stage as a process essential for the regulation of gene expression throughout development. In this review, we analyze recent findings on the identification of factors functioning in the regulation of the transcriptional elongation checkpoint control (TECC) stage of gene expression and how the factors' misregulation is associated with disease pathogenesis, including cancer.

KW - Cancer

KW - Chromatin

KW - Elongation

KW - RNA polymerase II

KW - Transcription

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Transcriptional elongation checkpoint control in development and disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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