TY - GEN
T1 - Transcriptional enhancers
T2 - 21st Century Genetics Genes at Work, 2015
AU - Ren, Bing
AU - Yue, Feng
N1 - Publisher Copyright:
© 2015 Cold Spring Harbor Laboratory Press.
PY - 2016
Y1 - 2016
N2 - Enhancers play a major role in animal development by modulating spatiotemporal expression of genes. They interact with sequence-specific transcriptional regulators in response to internal and external cues to bring about transcriptional changes, thus serving as the critical link between an organism's genome and its phenotypic traits. Deciphering the biology of enhancers is a key to understanding the genetic basis of common human diseases. Although a large number of candidate enhancers have been annotated through genome-wide analyses of chromatin accessibility, transcription factor binding, and histone modification in diverse cell types, efforts to characterize their biological roles in human diseases have only begun. Recent experiments have suggested a role for the three-dimensional chromatin architecture in regulation of gene expression by enhancers.
AB - Enhancers play a major role in animal development by modulating spatiotemporal expression of genes. They interact with sequence-specific transcriptional regulators in response to internal and external cues to bring about transcriptional changes, thus serving as the critical link between an organism's genome and its phenotypic traits. Deciphering the biology of enhancers is a key to understanding the genetic basis of common human diseases. Although a large number of candidate enhancers have been annotated through genome-wide analyses of chromatin accessibility, transcription factor binding, and histone modification in diverse cell types, efforts to characterize their biological roles in human diseases have only begun. Recent experiments have suggested a role for the three-dimensional chromatin architecture in regulation of gene expression by enhancers.
UR - http://www.scopus.com/inward/record.url?scp=84978776432&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978776432&partnerID=8YFLogxK
U2 - 10.1101/sqb.2015.80.027219
DO - 10.1101/sqb.2015.80.027219
M3 - Conference contribution
C2 - 26582789
AN - SCOPUS:84978776432
SN - 9781621821472
T3 - Cold Spring Harbor Symposia on Quantitative Biology
SP - 17
EP - 26
BT - 21st Century Genetics Genes at Work, 2015
A2 - Grodzicker, Terri
A2 - Stillman, Bruce
A2 - Stewart, David
PB - Cold Spring Harbor Laboratory Press
Y2 - 26 May 2015 through 31 May 2015
ER -