Transcriptional integration of mitochondrial biogenesis

Richard C. Scarpulla, Rick B. Vega, Daniel P. Kelly*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

454 Scopus citations

Abstract

Gene regulatory factors encoded by the nuclear genome are essential for mitochondrial biogenesis and function. Some of these factors act exclusively within the mitochondria to regulate the control of mitochondrial transcription, translation, and other functions. Others govern the expression of nuclear genes required for mitochondrial metabolism and organelle biogenesis. The peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) family of transcriptional coactivators play a major role in transducing and integrating physiological signals governing metabolism, differentiation, and cell growth to the transcriptional machinery controlling mitochondrial functional capacity. Thus, the PGC-1 coactivators serve as a central component of the transcriptional regulatory circuitry that coordinately controls the energy-generating functions of mitochondria in accordance with the metabolic demands imposed by changing physiological conditions, senescence, and disease.

Original languageEnglish (US)
Pages (from-to)459-466
Number of pages8
JournalTrends in Endocrinology and Metabolism
Volume23
Issue number9
DOIs
StatePublished - Sep 2012

Keywords

  • Gene regulation
  • Metabolism
  • Mitochondria
  • Peroxisome proliferator-activated receptor (PPAR)
  • Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)
  • Transcription

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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