TY - JOUR
T1 - Transcriptional memory at the nuclear periphery
AU - Brickner, Jason H.
N1 - Funding Information:
I thank the members of the lab, as well as Andreas Matouschek, Rick Gaber, Jonathan Widom, Sandy Westerheide and Jacklyn Jansen for their helpful comments on the manuscript. JHB is supported by grant GM080484 from the National Institute of General Medical Sciences and the Baldwin Fund for Biomedical Research at Northwestern University.
PY - 2009/2
Y1 - 2009/2
N2 - A number of inducible yeast genes are targeted to the nuclear periphery upon transcriptional activation. However, when repressed again, the INO1 and GAL1 genes remain at the nuclear periphery for multiple generations. Retention at the nuclear periphery represents a novel type of transcriptional memory; the peripherally localized, recently repressed state of GAL1 is activated more rapidly than the nucleoplasmically localized long-term repressed state of GAL1. This rapid reactivation involves localization at the nuclear periphery, the SWI/SNF chromatin remodeling complex, the histone variant H2A.Z and the Gal1 protein itself. Here, I review what we have learned about this type of transcriptional memory in yeast, what remains to be resolved and the challenges associated with understanding such epigenetic phenomena.
AB - A number of inducible yeast genes are targeted to the nuclear periphery upon transcriptional activation. However, when repressed again, the INO1 and GAL1 genes remain at the nuclear periphery for multiple generations. Retention at the nuclear periphery represents a novel type of transcriptional memory; the peripherally localized, recently repressed state of GAL1 is activated more rapidly than the nucleoplasmically localized long-term repressed state of GAL1. This rapid reactivation involves localization at the nuclear periphery, the SWI/SNF chromatin remodeling complex, the histone variant H2A.Z and the Gal1 protein itself. Here, I review what we have learned about this type of transcriptional memory in yeast, what remains to be resolved and the challenges associated with understanding such epigenetic phenomena.
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U2 - 10.1016/j.ceb.2009.01.007
DO - 10.1016/j.ceb.2009.01.007
M3 - Review article
C2 - 19181512
AN - SCOPUS:60749090162
VL - 21
SP - 127
EP - 133
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
IS - 1
ER -