Transcriptional regulation in the human retrovirus HTLV-1

Paul F. Lindholm; Fatah Kashanchi; John N. Brady

doi:10.1016/1044-5773(93)80008-C

Transcriptional regulation in the human retrovirus HTLV-1

Paul F. Lindholm^*, Fatah Kashanchi, John N. Brady

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The control of HTLV-1 viral gene expression is complex and involves the regulation of mRNA synthesis by Tax₁ and post-transcriptional processing by Rex₁. The Tax₁ protein functions as a transcriptional transactivator of the HTL V-1 LTR and cellular genes through cooperation and association with cellular transcription factors which bind to the LTR. In this article, we discuss (1) the functional domains of the Tax₁ regulatory protein; (2) Tax₁ regulation of viral and cellular gene expression; (3) interaction of Tax₁ with cellular transcription factors; (4) the potential role of extracellular Tax₁ protein as a regulator of cellular gene expression. Understanding of the molecular mechanism by which Tax₁ transactivates viral and cellular genes will provide important insights into the interaction between the virus and the host cell during viral replication and transformation.

Original language	English (US)
Pages (from-to)	53-60
Number of pages	8
Journal	Seminars in Virology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/1044-5773(93)80008-C
State	Published - Jan 1 1993

Keywords

Cytokine
HTLV-1
Tax
Trans-activation
Transcription

ASJC Scopus subject areas

Immunology
Virology

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10.1016/1044-5773(93)80008-C

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abstract = "The control of HTLV-1 viral gene expression is complex and involves the regulation of mRNA synthesis by Tax1 and post-transcriptional processing by Rex1. The Tax1 protein functions as a transcriptional transactivator of the HTL V-1 LTR and cellular genes through cooperation and association with cellular transcription factors which bind to the LTR. In this article, we discuss (1) the functional domains of the Tax1 regulatory protein; (2) Tax1 regulation of viral and cellular gene expression; (3) interaction of Tax1 with cellular transcription factors; (4) the potential role of extracellular Tax1 protein as a regulator of cellular gene expression. Understanding of the molecular mechanism by which Tax1 transactivates viral and cellular genes will provide important insights into the interaction between the virus and the host cell during viral replication and transformation.",

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AU - Kashanchi, Fatah

AU - Brady, John N.

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N2 - The control of HTLV-1 viral gene expression is complex and involves the regulation of mRNA synthesis by Tax1 and post-transcriptional processing by Rex1. The Tax1 protein functions as a transcriptional transactivator of the HTL V-1 LTR and cellular genes through cooperation and association with cellular transcription factors which bind to the LTR. In this article, we discuss (1) the functional domains of the Tax1 regulatory protein; (2) Tax1 regulation of viral and cellular gene expression; (3) interaction of Tax1 with cellular transcription factors; (4) the potential role of extracellular Tax1 protein as a regulator of cellular gene expression. Understanding of the molecular mechanism by which Tax1 transactivates viral and cellular genes will provide important insights into the interaction between the virus and the host cell during viral replication and transformation.

AB - The control of HTLV-1 viral gene expression is complex and involves the regulation of mRNA synthesis by Tax1 and post-transcriptional processing by Rex1. The Tax1 protein functions as a transcriptional transactivator of the HTL V-1 LTR and cellular genes through cooperation and association with cellular transcription factors which bind to the LTR. In this article, we discuss (1) the functional domains of the Tax1 regulatory protein; (2) Tax1 regulation of viral and cellular gene expression; (3) interaction of Tax1 with cellular transcription factors; (4) the potential role of extracellular Tax1 protein as a regulator of cellular gene expression. Understanding of the molecular mechanism by which Tax1 transactivates viral and cellular genes will provide important insights into the interaction between the virus and the host cell during viral replication and transformation.

KW - Cytokine

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KW - Tax

KW - Trans-activation

KW - Transcription

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Transcriptional regulation in the human retrovirus HTLV-1

Abstract

Keywords

ASJC Scopus subject areas

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