TY - JOUR
T1 - Transcriptional regulation of RANTES expression in T lymphocytes
AU - Song, A.
AU - Nikolcheva, T.
AU - Krensky, A. M.
PY - 2000
Y1 - 2000
N2 - We first identified the RANTES chemokine as part of a search for genes expressed by T lymphocytes 'late', 3-5 days, after T-cell activation. The kinetics of expression of RANTES and a small number of other genes are unusual and the mechanism of such delayed expression is unknown. In order to uncover a mechanism for such 'late' expression, we identified and characterized the RANTES promoter and a novel transcription factor regulating RANTES expression in T lymphocytes. RANTES factor of late activated T lymphocytes (RFLAT)-1 is a member of the Kruppel-like family of transcription factors. Like RANTES, RFLAT-1 expression is 'late' after T-cell activation. But, unlike RANTES, regulation of RFLAT-1 expression appears to be translational rather than transcriptional.
AB - We first identified the RANTES chemokine as part of a search for genes expressed by T lymphocytes 'late', 3-5 days, after T-cell activation. The kinetics of expression of RANTES and a small number of other genes are unusual and the mechanism of such delayed expression is unknown. In order to uncover a mechanism for such 'late' expression, we identified and characterized the RANTES promoter and a novel transcription factor regulating RANTES expression in T lymphocytes. RANTES factor of late activated T lymphocytes (RFLAT)-1 is a member of the Kruppel-like family of transcription factors. Like RANTES, RFLAT-1 expression is 'late' after T-cell activation. But, unlike RANTES, regulation of RFLAT-1 expression appears to be translational rather than transcriptional.
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U2 - 10.1034/j.1600-065X.2000.17610.x
DO - 10.1034/j.1600-065X.2000.17610.x
M3 - Review article
C2 - 11138780
AN - SCOPUS:0033653644
VL - 177
SP - 236
EP - 245
JO - Immunological Reviews
JF - Immunological Reviews
SN - 0105-2896
ER -