Transcriptional Regulation of the Nephrogenic Mesenchyme and Its Progeny

Joo Seop Park*, Andrew P. McMahon

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The nephrogenic mesenchyme, or capping mesenchyme, is a reservoir of stem/progenitor cells for kidney development. At each round of branching of the neighboring ureteric epithelium, cells within the nephrogenic mesenchyme decide to remain uncommitted progenitors or to differentiate into renal vesicles (RV), the epithelial precursor unit that gives rise to each nephron. The Six2 transcription factor is required for the nephrogenic mesenchyme to maintain its progenitor status, whereas Wnt9b/β-catenin signaling initiates its differentiation. Genome-wide mapping of Six2 and β-catenin interactions at the DNA level revealed a complex interplay in the action of these factors in controlling cell decision making within the nephrogenic mesenchyme. Several lines of evidence have also linked a number of other regulatory factors, including Hox, Osr, Sall, and Wt family members, to these regulatory networks. Furthermore, genetic studies have highlighted the central role of Notch signaling, and the regional activity of a number of transcriptional factors including Lhx1, Pou3f3, Hnf1b, Mafb, and Tcf21 in subdividing RV derivatives into the physiologically distinct nephron segments that underpin nephron function.

Original languageEnglish (US)
Title of host publicationKidney Development, Disease, Repair and Regeneration
PublisherElsevier Science Ltd.
Pages67-74
Number of pages8
ISBN (Electronic)9780128004388
ISBN (Print)9780128001028
DOIs
StatePublished - Jan 1 2015

Keywords

  • Hox
  • Nephron progenitors
  • Osr1
  • Six2
  • β-Catensin

ASJC Scopus subject areas

  • General Medicine

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