Abstract
Purpose of Review: The molecular mechanisms of the bone disease associated with chronic kidney disease (CKD), called renal osteodystrophy (ROD), are poorly understood. New transcriptomics technologies may provide clinically relevant insights into the pathogenesis of ROD. This review summarizes current progress and limitations in the study and treatment of ROD, and in transcriptomics analyses of skeletal tissues. Recent Findings: ROD is characterized by poor bone quality and strength leading to increased risk of fracture. Recent studies indicate permanent alterations in bone cell populations during ROD. Single-cell transcriptomics analyses, successful at identifying specialized cell subpopulations in bone, have not yet been performed in ROD. Summary: ROD is a widespread poorly understood bone disease with limited treatment options. Transcriptomics analyses of bone are needed to identify the bone cell subtypes and their role in the pathogenesis of ROD, and to develop adequate diagnosis and treatment strategies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 254-261 |
| Number of pages | 8 |
| Journal | Current Osteoporosis Reports |
| Volume | 18 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 1 2020 |
Funding
This study was supported by grants from National Institute of Health to AM (R01DK101730) and VD (R01DK102815, R01DK114158).
Keywords
- Bone and mineral metabolism
- Bulk RNA sequencing
- Chronic kidney disease
- Renal osteodystrophy
- Single-cell RNA sequencing
- Transcriptomics
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
