Transcutaneous Auricular Vagus Nerve Stimulation Modulates Performance but Not Pupil Size During Nonnative Speech Category Learning

Jacie R. McHaney, William L. Schuerman, Matthew K. Leonard, Bharath Chandrasekaran*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Subthreshold transcutaneous auricular vagus nerve stimulation (taVNS) synchronized with behavioral training can selectively enhance nonnative speech category learning in adults. Prior work has demonstrated that behavioral performance increases when taVNS is paired with easier-to-learn Mandarin tone categories in native English listeners, relative to when taVNS is paired with harder-to-learn Mandarin tone categories or without taVNS. Mechanistically, this temporally precise plasticity has been attributed to noradrenergic modulation. However, prior work did not specifically utilize methodologies that indexed nor-adrenergic modulation and, therefore, was unable to explicitly test this hypothesis. Our goal for this study was to use pupillometry to gain mechanistic insights into taVNS behavioral effects. Method: Thirty-eight participants learned to categorize Mandarin tones while pupil-lometry was recorded. In a double-blinded design, participants were divided into two taVNS groups that, as in the prior study, differed according to whether taVNS was paired with easier-to-learn tones or harder-to-learn tones. Learning performance and pupillary responses were measured using linear mixed-effects models. Results: We found that taVNS did not have any tone-specific or group behav-ioral or pupillary effects. However, in an exploratory analysis, we observed that taVNS did lead to faster rates of learning on trials paired with stimulation, particularly for those who were stimulated at lower amplitudes. Conclusions: Our results suggest that pupillary responses may not be a reliable marker of locus coeruleus–norepinephrine system activity in humans. However, future research should systematically examine the effects of stimulation amplitude on both behavior and pupillary responses.

Original languageEnglish (US)
Pages (from-to)3825-3843
Number of pages19
JournalJournal of Speech, Language, and Hearing Research
Volume66
Issue number10
DOIs
StatePublished - Oct 2023

ASJC Scopus subject areas

  • Speech and Hearing
  • Language and Linguistics
  • Linguistics and Language

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