Transcutaneous glucose sensing by surface-enhanced spatially offset Raman spectroscopy in a rat model

Jonathan M. Yuen, Nilam C. Shah, Joseph T. Walsh, Matthew R. Glucksberg, Richard P. Van Duyne

Research output: Contribution to journalArticlepeer-review

143 Scopus citations

Abstract

This letter presents the first quantitative, in vivo, transcutaneous glucose measurements using surface enhanced Raman spectroscopy (SERS). Silver film over nanosphere (AgFON) surfaces were functionalized with a mixed self-assembled monolayer (SAM) and implanted subcutaneously in a Sprague-Dawley rat. The glucose concentration was monitored in the interstitial fluid. SER spectra were collected from the sensor chip through the skin using spatially offset Raman spectroscopy (SORS). The combination of SERS and SORS is a powerful new approach to the challenging problem of in vivo metabolite and drug sensing.

Original languageEnglish (US)
Pages (from-to)8382-8385
Number of pages4
JournalAnalytical Chemistry
Volume82
Issue number20
DOIs
StatePublished - Oct 15 2010

ASJC Scopus subject areas

  • Analytical Chemistry

Fingerprint Dive into the research topics of 'Transcutaneous glucose sensing by surface-enhanced spatially offset Raman spectroscopy in a rat model'. Together they form a unique fingerprint.

Cite this