Transcutaneous glucose sensing by surface-enhanced spatially offset Raman spectroscopy in a rat model

Jonathan M. Yuen; Nilam C. Shah; Joseph T. Walsh; Matthew R. Glucksberg; Richard P. Van Duyne

doi:10.1021/ac101951j

Transcutaneous glucose sensing by surface-enhanced spatially offset Raman spectroscopy in a rat model

Jonathan M. Yuen, Nilam C. Shah, Joseph T. Walsh, Matthew R. Glucksberg, Richard P. Van Duyne

Research output: Contribution to journal › Article › peer-review

160 Scopus citations

Abstract

This letter presents the first quantitative, in vivo, transcutaneous glucose measurements using surface enhanced Raman spectroscopy (SERS). Silver film over nanosphere (AgFON) surfaces were functionalized with a mixed self-assembled monolayer (SAM) and implanted subcutaneously in a Sprague-Dawley rat. The glucose concentration was monitored in the interstitial fluid. SER spectra were collected from the sensor chip through the skin using spatially offset Raman spectroscopy (SORS). The combination of SERS and SORS is a powerful new approach to the challenging problem of in vivo metabolite and drug sensing.

Original language	English (US)
Pages (from-to)	8382-8385
Number of pages	4
Journal	Analytical Chemistry
Volume	82
Issue number	20
DOIs	https://doi.org/10.1021/ac101951j
State	Published - Oct 15 2010

ASJC Scopus subject areas

Analytical Chemistry

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title = "Transcutaneous glucose sensing by surface-enhanced spatially offset Raman spectroscopy in a rat model",

abstract = "This letter presents the first quantitative, in vivo, transcutaneous glucose measurements using surface enhanced Raman spectroscopy (SERS). Silver film over nanosphere (AgFON) surfaces were functionalized with a mixed self-assembled monolayer (SAM) and implanted subcutaneously in a Sprague-Dawley rat. The glucose concentration was monitored in the interstitial fluid. SER spectra were collected from the sensor chip through the skin using spatially offset Raman spectroscopy (SORS). The combination of SERS and SORS is a powerful new approach to the challenging problem of in vivo metabolite and drug sensing.",

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AU - Yuen, Jonathan M.

AU - Shah, Nilam C.

AU - Walsh, Joseph T.

AU - Glucksberg, Matthew R.

AU - Van Duyne, Richard P.

PY - 2010/10/15

Y1 - 2010/10/15

N2 - This letter presents the first quantitative, in vivo, transcutaneous glucose measurements using surface enhanced Raman spectroscopy (SERS). Silver film over nanosphere (AgFON) surfaces were functionalized with a mixed self-assembled monolayer (SAM) and implanted subcutaneously in a Sprague-Dawley rat. The glucose concentration was monitored in the interstitial fluid. SER spectra were collected from the sensor chip through the skin using spatially offset Raman spectroscopy (SORS). The combination of SERS and SORS is a powerful new approach to the challenging problem of in vivo metabolite and drug sensing.

AB - This letter presents the first quantitative, in vivo, transcutaneous glucose measurements using surface enhanced Raman spectroscopy (SERS). Silver film over nanosphere (AgFON) surfaces were functionalized with a mixed self-assembled monolayer (SAM) and implanted subcutaneously in a Sprague-Dawley rat. The glucose concentration was monitored in the interstitial fluid. SER spectra were collected from the sensor chip through the skin using spatially offset Raman spectroscopy (SORS). The combination of SERS and SORS is a powerful new approach to the challenging problem of in vivo metabolite and drug sensing.

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Transcutaneous glucose sensing by surface-enhanced spatially offset Raman spectroscopy in a rat model

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