Transdermal estradiol treatment during breastfeeding: maternal and infant serum concentrations

Emily Pinheiro*, Debra L. Bogen, Denada Hoxha, Katherine L. Wisner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


We examined estradiol (E2) and estrone (E1) concentrations in breastfeeding mother-infant dyads. The mothers had postpartum depression and were participants in a randomized clinical trial with three treatments (transdermal E2, sertraline, and placebo). Neither infant E1 and E2 concentrations nor infant growth differed across the treatments. Transdermal E2 administration of 50 to 200 mcg/day for breastfeeding women did not affect infant E1 or E2 concentrations or infant growth.

Original languageEnglish (US)
Pages (from-to)409-413
Number of pages5
JournalArchives of Women's Mental Health
Issue number2
StatePublished - Apr 1 2016


  • Breastfeeding
  • Estradiol
  • Infant
  • Major depressive disorder
  • Postpartum depression

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Psychiatry and Mental health


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