Transdominant regulation of integrin function: Mechanisms of crosstalk

Annette M. Gonzalez*, Ramona Bhattacharya, Gregory W. deHart, Jonathan C.R. Jones

*Corresponding author for this work

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Transdominant inhibition of integrins or integrin-integrin crosstalk is an important regulator of integrin ligand binding and subsequent signaling events that control a variety of cell functions in many tissues. Here we discuss examples of integrin crosstalk and detail our current understanding of the molecular mechanisms that are involved in this receptor phenomenon. The cytoskeleton associated protein talin is a key regulator of integrin crosstalk. We describe how the interaction of talin and the cytoplasmic tail of β integrin is controlled and how competitive inhibitors of this binding play a role in integrin crosstalk. We conclude with a discussion of how integrin crosstalk impacts the interpretation of integrin inhibitor and knockdown studies in both the laboratory and clinical setting.

Original languageEnglish (US)
Pages (from-to)578-583
Number of pages6
JournalCellular Signalling
Volume22
Issue number4
DOIs
StatePublished - Apr 2010

Keywords

  • Adaptor proteins
  • Cytoskeleton
  • Matrix adhesion
  • Phosphorylation
  • Receptors
  • Signaling

ASJC Scopus subject areas

  • Cell Biology

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