Transduction of hematopoietic stem cells with a retroviral vector expressing the neomycin phosphotransferase gene

C. J. Link*, T. Seregina, M. Edleman, W. B. Young, R. K. Burt, S. Kisselev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Transduction of stem cells with a marking gene holds promise to determine if tissue repair or regeneration is derived from the adult hematopoietic stem cell and if relapse of an autoimmune disease should occur whether relapse arises from the stem cell compartment or from lymphocytes surviving the conditioning regimen. New safety concerns about gene-modified stem cell would entail new safety testing such as documentation of the insertional site prior to release.

Original languageEnglish (US)
Pages (from-to)S33-S35
JournalBone Marrow Transplantation
Volume32
DOIs
StatePublished - Aug 2003

Keywords

  • Autoimmune disease
  • Gene transduction
  • Stem cells

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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