Transendothelial function of human metastatic melanoma cells: Role of the microenvironment in cell-fate determination

Mary J.C. Hendrix, Richard E.B. Seftor, Elisabeth A. Seftor, Lynn M. Gruman, Lisa M.L. Lee, Don D. Sheriff, Gina C. Schatteman, Richard E.B. Seftor, Elisabeth A. Seftor, Mary J.C. Hendrix, Brian J. Nickoloff, Lucio Miele

Research output: Contribution to journalArticlepeer-review

102 Scopus citations

Abstract

On the basis of the ability of aggressive melanoma cells to participate in vasculogenic mimicry, particularly their expression of endothelial-associated genes, we examined the plasticity of human metastatic cutaneous melanoma cells with respect to vascular function. Fluorescently labeled metastatic melanoma cells were challenged to an ischemic microenvironment surgically induced in the hind limbs of nude mice. The data reveal the capability of these melanoma cells to express cell-fate determination molecules, normally expressed during embryonic vasculogenesis, and to participate in the neovascularization of circulation-deficient muscle. These results demonstrate the powerful influence of the microenvironment on the transendothelial differentiation of aggressive melanoma cells, and may provide new perspectives on tumor cell plasticity that could be exploited for novel therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)665-668
Number of pages4
JournalCancer Research
Volume62
Issue number3
StatePublished - Feb 1 2002

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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