Transepidermal water loss in the orphan forms of ichthyosis

Taylor R. Erickson, Morgan B. Murphrey, Hajar Abu-Zayed, Benedict Wu, Erin Ibler, Stephanie M. Rangel, Amy S. Paller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


As a surrogate measure of skin barrier dysfunction, we sought to determine differences in transepidermal water loss (TEWL) among ichthyosis subtypes and correlate TEWL with clinical severity. Subjects with Netherton syndrome had the highest TEWL values (increased water loss), while TEWL values were lowest in subjects with epidermolytic ichthyosis. TEWL correlated with severity only in lamellar ichthyosis and age was inversely correlated with TEWL (rs = −.213, P =.02). TEWL is an objective measure that complements disease severity in ichthyosis and may be used as an adjuvant to monitor treatment response.

Original languageEnglish (US)
Pages (from-to)771-773
Number of pages3
JournalPediatric dermatology
Issue number4
StatePublished - Jul 1 2020


  • Ichthyosis
  • skin barrier

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dermatology

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