Transforaminal Intrathecal Access for Injection of Nusinersen in Adult and Pediatric Patients with Spinal Muscular Atrophy

Tahaamin Shokuhfar, Ramez N. Abdalla, Michael C. Hurley, Pouya Nazari, Sameer A. Ansari, Senda Ajroud-Driss, Nancy Kuntz, Subhan Azmi, Vamshi Rao, Ali Shaibani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The main purpose of this article is to assess the safety and efficacy of transforaminal lumbar puncture for the injection of nusinersen (Spinraza) in patients with extensive spinal fusion and/or scoliosis. A retrospective chart reviews of all spinal muscular atrophy patients (adults and children) were conducted. Demographic data, procedure details, follow-ups, and related complications were recorded. We performed 85 transforaminal injections in nine pediatric patients (5 male and 4 female) aged between 8 and 17 years (mean = 11 years) and seven adult patients (5 females and 2 males) aged between 24 and 41 years (mean= 30 years). Fluoroscopy guidance was used in 87% of our patients. No major complication was reported. Fluoroscopy-guided transforaminal nusinersen injection is a safe and successful alternative approach in adult and pediatric patients with severe spinal scoliosis, interlaminar osseous fusion, and spinal fusion hardware.

Original languageEnglish (US)
Pages (from-to)88-94
Number of pages7
JournalJournal of Pediatric Neurology
Volume18
Issue number2
DOIs
StatePublished - Apr 1 2020

Keywords

  • lumbar puncture
  • spinal muscular atrophy
  • transforaminal

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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