Transformed non-Hodgkin lymphoma in the rituximab era: Analysis of the NCCN outcomes database

Makiko Ban-Hoefen, Ann Vanderplas, Allison L. Crosby-Thompson, Gregory A. Abel, Myron S. Czuczman, Leo I. Gordon, Mark S. Kaminski, Jennifer Kelly, Michael Millenson, Auayporn P. Nademanee, Maria A. Rodriguez, Andrew D. Zelenetz, Joyce Niland, Ann S. Lacasce, Jonathan W. Friedberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Histological transformation (HT) is a major cause of morbidity and mortality in patients with indolent non-Hodgkin lymphoma (NHL). The multicentre National Cancer Comprehensive Network database for NHL provides a unique opportunity to investigate the natural history of HT in the rituximab era. 118 patients with biopsy-confirmed indolent lymphoma and subsequent biopsy-confirmed HT were identified. Treatments for HT included autologous stem-cell transplant (auto-SCT) (n = 50), allogeneic SCT (allo-SCT) (n = 18), and treatment without transplant (n = 50). The 2-year overall survival (OS) for the entire cohort was 68%. For auto-SCT patients aged ≤60 years (n = 24), the 2-year OS was 74%. For non-transplanted patients aged ≤60 years (n = 19), the 2-year OS was 59%. The 2-year OS of patients naïve to chemotherapy prior to HT was superior to patients who were exposed to chemotherapy prior to HT (100% vs. 35%, P = 0·03). In this largest prospective cohort of patients of strictly defined HT in the rituximab era, the natural history of HT appears more favourable than historical studies. Younger patients who were not exposed to chemotherapy prior to HT experienced a prolonged survival even without transplantation. This study serves as a benchmark for future trials of novel approaches for HT in the Rituximab era.

Original languageEnglish (US)
Pages (from-to)487-495
Number of pages9
JournalBritish Journal of Haematology
Volume163
Issue number4
DOIs
StatePublished - Nov 2013

Keywords

  • Diffuse large B-cell lymphoma
  • Histological transformation
  • Non-Hodgkin lymphoma
  • Rituximab era
  • Stem-cell transplantation

ASJC Scopus subject areas

  • Hematology

Fingerprint

Dive into the research topics of 'Transformed non-Hodgkin lymphoma in the rituximab era: Analysis of the NCCN outcomes database'. Together they form a unique fingerprint.

Cite this