Transforming growth factor-β1-induced proliferation of the prostate cancer cell line, TSU-Pr1: The role of platelet-derived growth factor

Sharon M. Sintich, Marilyn L.G. Lamm, Julia A. Sensibar, Chung Lee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The results of our previous study revealed that transforming growth factor-β1 (TGFβ1) stimulated proliferation of the prostate cancer cell line, TSU-Pr1. This observation is unexpected, for TGFβ usually inhibits proliferation in prostate cancer cells. The present study examines possible mechanisms through which TGFβ1 induces this proliferation. We postulate that TGFβ1 action is mediated through an indirect mechanism by inducing the expression of platelet derived growth factor (PDGF), which, in turn, stimulates proliferation. The TGFβ1-induced proliferation can be abrogated by treatment with a PDGF-neutralizing antibody. Treatment with exogenous PDGF significantly increased TSU-Pr1 proliferation. Finally, treatment of TSU-Pr1 cells with TGFβ1 resulted in an increase in PDGF secretion. These results indicate that TGFβ1-induced proliferation in TSU-Pr1 cells is at least mediated through an increased secretion of PDGF.

Original languageEnglish (US)
Pages (from-to)3411-3415
Number of pages5
JournalEndocrinology
Volume140
Issue number8
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Endocrinology

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