Transforming growth factor-beta (TGFβ) is chemotactic for human monocytes and induces their expression of angiogenic activity

David M. Wiseman*, Peter J. Polverini, David W. Kamp, S. Joseph Leibovich

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

179 Scopus citations

Abstract

TGFβ stimulates human blood monocyte migration, with peak migratory response occurring consistently at a concentration of 16-100fg/ml. Checkerboard analysis revealed both chemotactic and chemokinetic components to this response. At higher concentrations (10-100pg/ml), TGFβ stimulated expression of angiogenic activity by monocytes. While mRNA for TNFα was undetectable in resting monocytes, high steady state levels of TNFα mRNA were rapidy induced in TGFβ-treated monocytes. TGFβ is secreted by a number of neoplastic cells as well as normal cells such as platelets and lymphocytes. TGFβ may recruit monocytes from the circulation, and subsequently activate them to express angiogenic activities such as TNFα, thus playing an important role in wound repair, inflammation and tumor growth.

Original languageEnglish (US)
Pages (from-to)793-800
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume157
Issue number2
DOIs
StatePublished - Dec 15 1988

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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