TGFβ stimulates human blood monocyte migration, with peak migratory response occurring consistently at a concentration of 16-100fg/ml. Checkerboard analysis revealed both chemotactic and chemokinetic components to this response. At higher concentrations (10-100pg/ml), TGFβ stimulated expression of angiogenic activity by monocytes. While mRNA for TNFα was undetectable in resting monocytes, high steady state levels of TNFα mRNA were rapidy induced in TGFβ-treated monocytes. TGFβ is secreted by a number of neoplastic cells as well as normal cells such as platelets and lymphocytes. TGFβ may recruit monocytes from the circulation, and subsequently activate them to express angiogenic activities such as TNFα, thus playing an important role in wound repair, inflammation and tumor growth.
|Original language||English (US)|
|Number of pages||8|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Dec 15 1988|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology