Transitive inference reasoning is impaired by focal lesions in parietal cortex rather than rostrolateral prefrontal cortex

Randall L. Waechter*, Vinod Goel, Vanessa Raymont, Frank Kruger, Jordan Grafman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Transitive inference reasoning involves the examination and comparison of a given number of relational pairs in order to understand overall group hierarchy (e.g., A>B, B>C, C>D; therefore is A>D?). A number of imaging studies have demonstrated the role of the parietal cortex for resolving transitive inferences. Some studies also identify the rostrolateral prefrontal cortex as being critical for "relational integration" processes supporting transitive reasoning. To clarify this issue, we carried out a transitive inference study involving neurological patients with focal lesions to the rostrolateral prefrontal (n=5) or parietal cortices (n=7), as well as normal controls (n=6). The patients and controls were statistically matched on age, education, pre-injury IQ, general memory, working memory, and performance/full IQ, though the rostrolateral patients did score significantly higher than the normal controls on verbal IQ. Results indicate that patients with focal lesions to the parietal cortex were impaired in the task relative to both the patients with focal lesions to rostrolateral prefrontal cortex and the control group, and there was no difference in task performance between the rostrolateral prefrontal and the control groups. This result continued to hold after controlling for verbal IQ as a covariate. These findings point to a critical role for the parietal cortex, rather than the rostrolateral prefrontal, in transitive inference. Since the groups performed similarly on a working memory task, working memory cannot fully account for the result, suggesting a specific role of parietal cortex in transitive inference.

Original languageEnglish (US)
Pages (from-to)464-471
Number of pages8
Issue number3
StatePublished - Feb 2013


  • BA 10
  • BA 7
  • Parietal cortex
  • Rostrolateral prefrontal cortex
  • Transitive inference

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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