Translating exercise benefits in sickle cell disease

Dan M. Cooper, Robert I. Liem

Research output: Contribution to journalReview articlepeer-review


The pathophysiologic basis for reduced fitness in sickle cell disease (SCD) is multifactorial and characterized by impaired oxygen-carrying capacity, derangements in the cardiopulmonary response to exercise, and abnormal metabolic responses in working muscles. In this issue of Blood, Merlet et al1 demonstrated in a provocative and elegant study that exercise training led to muscle capillary growth in people with SCD.

Original languageEnglish (US)
Pages (from-to)2227-2229
Number of pages3
Issue number25
StatePublished - Dec 19 2019

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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