Translating the Science of Psoriasis

Kenneth B. Gordon

doi:10.12788/J.SDER.2016.017

Translating the Science of Psoriasis

Kenneth B. Gordon

Dermatology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Knowledge about the pathophysiology of psoriasis has evolved substantially in recent years, since the identification of the T helper 17 (Th17) cells. Cytokines produced by these cells appear to play major roles in psoriatic inflammation. The cytokine interleukin (IL)-23 appears to promote regulatory T cells to differentiate into Th17 cells. Available and investigational therapies act on targets within these pathways.

Original language	English (US)
Journal	Seminars in cutaneous medicine and surgery
Volume	35
Issue number	4 S
DOIs	https://doi.org/10.12788/J.SDER.2016.017
State	Published - 2016

Keywords

IL-17
IL-23
Psoriasis treatment
Th17 pathway

ASJC Scopus subject areas

Surgery
Dermatology

Access to Document

10.12788/J.SDER.2016.017

Cite this

@article{74fbbaa0587d4be986d3f1d32871daae,

title = "Translating the Science of Psoriasis",

abstract = "Knowledge about the pathophysiology of psoriasis has evolved substantially in recent years, since the identification of the T helper 17 (Th17) cells. Cytokines produced by these cells appear to play major roles in psoriatic inflammation. The cytokine interleukin (IL)-23 appears to promote regulatory T cells to differentiate into Th17 cells. Available and investigational therapies act on targets within these pathways.",

keywords = "IL-17, IL-23, Psoriasis treatment, Th17 pathway",

author = "Gordon, {Kenneth B.}",

note = "Funding Information: Publication of this CME/CE article was jointly provided by Rutgers, The State University of New Jersey and Global Academy for Medical Education, LLC with Skin Disease Education Foundation (SDEF) and is supported by educational grants from AbbVie Inc. and Novartis Pharmaceuticals Corporation. Publisher Copyright: All content copyright {\textcopyright} 2021 Global Academy for Medical Education LLC. All rights reserved.",

year = "2016",

doi = "10.12788/J.SDER.2016.017",

language = "English (US)",

volume = "35",

journal = "Seminars in cutaneous medicine and surgery",

issn = "1085-5629",

publisher = "W.B. Saunders Ltd",

number = "4 S",

}

TY - JOUR

T1 - Translating the Science of Psoriasis

AU - Gordon, Kenneth B.

N1 - Funding Information: Publication of this CME/CE article was jointly provided by Rutgers, The State University of New Jersey and Global Academy for Medical Education, LLC with Skin Disease Education Foundation (SDEF) and is supported by educational grants from AbbVie Inc. and Novartis Pharmaceuticals Corporation. Publisher Copyright: All content copyright © 2021 Global Academy for Medical Education LLC. All rights reserved.

PY - 2016

Y1 - 2016

N2 - Knowledge about the pathophysiology of psoriasis has evolved substantially in recent years, since the identification of the T helper 17 (Th17) cells. Cytokines produced by these cells appear to play major roles in psoriatic inflammation. The cytokine interleukin (IL)-23 appears to promote regulatory T cells to differentiate into Th17 cells. Available and investigational therapies act on targets within these pathways.

AB - Knowledge about the pathophysiology of psoriasis has evolved substantially in recent years, since the identification of the T helper 17 (Th17) cells. Cytokines produced by these cells appear to play major roles in psoriatic inflammation. The cytokine interleukin (IL)-23 appears to promote regulatory T cells to differentiate into Th17 cells. Available and investigational therapies act on targets within these pathways.

KW - IL-17

KW - IL-23

KW - Psoriasis treatment

KW - Th17 pathway

UR - http://www.scopus.com/inward/record.url?scp=84988485517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988485517&partnerID=8YFLogxK

U2 - 10.12788/J.SDER.2016.017

DO - 10.12788/J.SDER.2016.017

M3 - Article

C2 - 27526392

AN - SCOPUS:84988485517

SN - 1085-5629

VL - 35

JO - Seminars in cutaneous medicine and surgery

JF - Seminars in cutaneous medicine and surgery

IS - 4 S

ER -

Translating the Science of Psoriasis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this