Translating the Science of Psoriasis

Kenneth B. Gordon

doi:10.12788/J.SDER.2016.017

Translating the Science of Psoriasis

Kenneth B. Gordon

Dermatology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Knowledge about the pathophysiology of psoriasis has evolved substantially in recent years, since the identification of the T helper 17 (Th17) cells. Cytokines produced by these cells appear to play major roles in psoriatic inflammation. The cytokine interleukin (IL)-23 appears to promote regulatory T cells to differentiate into Th17 cells. Available and investigational therapies act on targets within these pathways.

Original language	English (US)
Journal	Seminars in cutaneous medicine and surgery
Volume	35
Issue number	4 S
DOIs	https://doi.org/10.12788/J.SDER.2016.017
State	Published - 2016

Funding

Publication of this CME/CE article was jointly provided by Rutgers, The State University of New Jersey and Global Academy for Medical Education, LLC with Skin Disease Education Foundation (SDEF) and is supported by educational grants from AbbVie Inc. and Novartis Pharmaceuticals Corporation.

Keywords

IL-17
IL-23
Psoriasis treatment
Th17 pathway

ASJC Scopus subject areas

Surgery
Dermatology

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10.12788/J.SDER.2016.017

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title = "Translating the Science of Psoriasis",

abstract = "Knowledge about the pathophysiology of psoriasis has evolved substantially in recent years, since the identification of the T helper 17 (Th17) cells. Cytokines produced by these cells appear to play major roles in psoriatic inflammation. The cytokine interleukin (IL)-23 appears to promote regulatory T cells to differentiate into Th17 cells. Available and investigational therapies act on targets within these pathways.",

keywords = "IL-17, IL-23, Psoriasis treatment, Th17 pathway",

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note = "Funding Information: Publication of this CME/CE article was jointly provided by Rutgers, The State University of New Jersey and Global Academy for Medical Education, LLC with Skin Disease Education Foundation (SDEF) and is supported by educational grants from AbbVie Inc. and Novartis Pharmaceuticals Corporation. Publisher Copyright: All content copyright {\textcopyright} 2021 Global Academy for Medical Education LLC. All rights reserved.",

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N1 - Funding Information: Publication of this CME/CE article was jointly provided by Rutgers, The State University of New Jersey and Global Academy for Medical Education, LLC with Skin Disease Education Foundation (SDEF) and is supported by educational grants from AbbVie Inc. and Novartis Pharmaceuticals Corporation. Publisher Copyright: All content copyright © 2021 Global Academy for Medical Education LLC. All rights reserved.

PY - 2016

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N2 - Knowledge about the pathophysiology of psoriasis has evolved substantially in recent years, since the identification of the T helper 17 (Th17) cells. Cytokines produced by these cells appear to play major roles in psoriatic inflammation. The cytokine interleukin (IL)-23 appears to promote regulatory T cells to differentiate into Th17 cells. Available and investigational therapies act on targets within these pathways.

AB - Knowledge about the pathophysiology of psoriasis has evolved substantially in recent years, since the identification of the T helper 17 (Th17) cells. Cytokines produced by these cells appear to play major roles in psoriatic inflammation. The cytokine interleukin (IL)-23 appears to promote regulatory T cells to differentiate into Th17 cells. Available and investigational therapies act on targets within these pathways.

KW - IL-17

KW - IL-23

KW - Psoriasis treatment

KW - Th17 pathway

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ER -

Translating the Science of Psoriasis

Abstract

Funding

Keywords

ASJC Scopus subject areas

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