Translating the Science of Psoriasis

Kenneth B. Gordon

doi:10.12788/j.sder.2016.017

Translating the Science of Psoriasis

Kenneth B. Gordon

Dermatology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Knowledge about the pathophysiology of psoriasis has evolved substantially in recent years, since the identification of the T helper 17 (Th17) cells. Cytokines produced by these cells appear to play major roles in psoriatic inflammation. The cytokine interleukin (IL)-23 appears to promote regulatory T cells to differentiate into Th17 cells. Available and investigational therapies act on targets within these pathways.

Original language	English (US)
Pages (from-to)	S64
Journal	Seminars in cutaneous medicine and surgery
Volume	35
Issue number	4
DOIs	https://doi.org/10.12788/j.sder.2016.017
State	Published - Jun 1 2016

Keywords

IL-17
IL-23
Psoriasis treatment
Th17 pathway

ASJC Scopus subject areas

Surgery
Dermatology

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10.12788/j.sder.2016.017

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title = "Translating the Science of Psoriasis",

abstract = "Knowledge about the pathophysiology of psoriasis has evolved substantially in recent years, since the identification of the T helper 17 (Th17) cells. Cytokines produced by these cells appear to play major roles in psoriatic inflammation. The cytokine interleukin (IL)-23 appears to promote regulatory T cells to differentiate into Th17 cells. Available and investigational therapies act on targets within these pathways.",

keywords = "IL-17, IL-23, Psoriasis treatment, Th17 pathway",

author = "Gordon, {Kenneth B.}",

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N2 - Knowledge about the pathophysiology of psoriasis has evolved substantially in recent years, since the identification of the T helper 17 (Th17) cells. Cytokines produced by these cells appear to play major roles in psoriatic inflammation. The cytokine interleukin (IL)-23 appears to promote regulatory T cells to differentiate into Th17 cells. Available and investigational therapies act on targets within these pathways.

AB - Knowledge about the pathophysiology of psoriasis has evolved substantially in recent years, since the identification of the T helper 17 (Th17) cells. Cytokines produced by these cells appear to play major roles in psoriatic inflammation. The cytokine interleukin (IL)-23 appears to promote regulatory T cells to differentiate into Th17 cells. Available and investigational therapies act on targets within these pathways.

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KW - IL-23

KW - Psoriasis treatment

KW - Th17 pathway

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Translating the Science of Psoriasis

Abstract

Keywords

ASJC Scopus subject areas

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