Abstract
Knowledge about the pathophysiology of psoriasis has evolved substantially in recent years, since the identification of the T helper 17 (Th17) cells. Cytokines produced by these cells appear to play major roles in psoriatic inflammation. The cytokine interleukin (IL)-23 appears to promote regulatory T cells to differentiate into Th17 cells. Available and investigational therapies act on targets within these pathways.
Original language | English (US) |
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Journal | Seminars in cutaneous medicine and surgery |
Volume | 35 |
Issue number | 4 S |
DOIs | |
State | Published - 2016 |
Keywords
- IL-17
- IL-23
- Psoriasis treatment
- Th17 pathway
ASJC Scopus subject areas
- Surgery
- Dermatology