Translation molekularer zusammenhänge in die klinische anwendung. Dargestellt am beispiel des vascular-endothelial-growth-factor-(VEGF-)pathway

Translated title of the contribution: Translational research in renal cell cancer. Illustrated by the example of the vascular endothelial growth factor pathway

R. Kuefer, M. Autenrieth, K. Herkommer, P. Blum, A. Merseburger, M. Hofer, L. Rinnab, J. Gschwend, M. Ringhoffer*

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

For patients with metastatic renal cell cancer (RCC), therapeutic options after cytokine failure are rather limited. There is a considerable need to identify new substances for systemic therapy. Due to upregulation after the loss of a functional von Hippel Lindau gene product, the vascular endothelial growth factor (VEGF) pathway is a promising target for a molecular based therapy. Over the last few years, therapeutic agents have been developed which inhibit this pathway at various levels. Here, we provide an overview of the molecular background and currently used drugs which have entered clinical trials in the setting of metastatic RCC disease. Until now, the results from early clinical trials are very promising, however, the best schedule, dosage, potential combination regimens, as well as long time efficacy, are still to be determined.

Translated title of the contributionTranslational research in renal cell cancer. Illustrated by the example of the vascular endothelial growth factor pathway
Original languageGerman
Pages (from-to)328-335
Number of pages8
JournalUrologe - Ausgabe A
Volume45
Issue number3
DOIs
StatePublished - Mar 1 2006

Keywords

  • Clear cell renal carcinoma
  • Metastases
  • Targeted therapy
  • VEGF

ASJC Scopus subject areas

  • Urology

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