@article{ceda974a6ea245a6bc0092e6954f7d85,
title = "Translocated microbiome composition determines immunological outcome in treated HIV infection",
abstract = "The impact of the microbiome on HIV disease is widely acknowledged although the mechanisms downstream of fluctuations in microbial composition remain speculative. We detected rapid, dynamic changes in translocated microbial constituents during two years after cART initiation. An unbiased systems biology approach revealed two distinct pathways driven by changes in the abundance ratio of Serratia to other bacterial genera. Increased CD4 T cell numbers over the first year were associated with high Serratia abundance, pro-inflammatory innate cytokines, and metabolites that drive Th17 gene expression signatures and restoration of mucosal integrity. Subsequently, decreased Serratia abundance and downregulation of innate cytokines allowed re-establishment of systemic T cell homeostasis promoting restoration of Th1 and Th2 gene expression signatures. Analyses of three other geographically distinct cohorts of treated HIV infection established a more generalized principle that changes in diversity and composition of translocated microbial species influence systemic inflammation and consequently CD4 T cell recovery.",
keywords = "antiretroviral therapy, HIV, inflammation, microbiome, systems biology",
author = "Krystelle Nganou-Makamdop and Aarthi Talla and Sharma, {Ashish Arunkumar} and Sam Darko and Amy Ransier and Farida Laboune and Chipman, {Jeffrey G.} and Beilman, {Gregory J.} and Torfi Hoskuldsson and Slim Fourati and Schmidt, {Thomas E.} and Sahaana Arumugam and Lima, {Noemia S.} and Damee Moon and Samuel Callisto and Jordan Schoephoerster and Jeffery Tomalka and Peter Mugyenyi and Francis Ssali and Proscovia Muloma and Patrick Ssengendo and Leda, {Ana R.} and Cheu, {Ryan K.} and Flynn, {Jacob K.} and Antigoni Morou and Elsa Brunet-Ratnasingham and Benigno Rodriguez and Lederman, {Michael M.} and Kaufmann, {Daniel E.} and Klatt, {Nichole R.} and Cissy Kityo and Brenchley, {Jason M.} and Schacker, {Timothy W.} and Sekaly, {Rafick P.} and Douek, {Daniel C.}",
note = "Funding Information: This work was funded in part by the intramural program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH); NIH grant R01-AI124965 to T.W.S.; Center for AIDS Research and Fasenmyer Foundation ( AI 36219 CWRU to M.M.L.), Canadian Institute for Health Research (CIHR) ( CIHR-168901 and NIH grant R01-HL092565 to D.E.K.); and NIH grants R01-DA043263 , R01-DA042712 , and R37-AI141258 to R.P.S. Bacterial cultures were supported by NIH grant R01-DK112254 to N.R.K. We thank R. Dutt with help processing samples. This work made use of the High Performance Computing Resources in the Core Facility for Advanced Research Computing at Case Western Reserve University. Publisher Copyright: {\textcopyright} 2021",
year = "2021",
month = jul,
day = "22",
doi = "10.1016/j.cell.2021.05.023",
language = "English (US)",
volume = "184",
pages = "3899--3914.e16",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "15",
}