TY - JOUR
T1 - Translocation (3;21;8)(q21;q22;q22) in a patient with acute myeloid leukemia
T2 - A case report and review of prognostic indicators
AU - Giles, Francis Joseph
AU - Kanemaki, Trent Jon
AU - Schreck, Rhona Rebecca
AU - Qasabian, Levon
AU - Fuerst, Marie Perelli
AU - Lim, Stephen Wong
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998/7
Y1 - 1998/7
N2 - We report a patient with acute myeloid leukemia (AML) and t(3;21;8)(q21;q22;q22). This translocation has not been previously described in de nova or relapsed AML. The patient is a 25-year-old woman who presented with WBC 6.2 x 109/L, Hgb 10.2 g/dL, Hct 28.4%, and platelets 67 x 109/L. A bone marrow biopsy revealed a 70% hematopoietic cellularity with 65% blasts. Immunophenotyping showed aberrant expression of lymphoid-associated marker CD19. Cytogenetic analysis on a 72-hour culture of bone marrow cells supplemented with conditioned media was evaluated by G-banding at about the 400-band level. The patient's age, cytogenetics, WBC, and immunophenotype at diagnosis would seem to suggest a favorable prognosis, according to previous studies of prognostic indicators. She was treated with induction and consolidation chemotherapy, followed by myeloablative conditioning and autologous peripheral blood stem cell transplant (PBSCT). Despite multiple favorable prognostic factors, the patient relapsed 7 months after PBSCT. Translocation of chromosomes 8 and 21 is common in AML and is generally considered a good prognostic factor. We suspect that the effect of the 3q21 translocation in an otherwise favorable translocation of chromosomes 8 and 21 may be responsible for this patient's early relapse.
AB - We report a patient with acute myeloid leukemia (AML) and t(3;21;8)(q21;q22;q22). This translocation has not been previously described in de nova or relapsed AML. The patient is a 25-year-old woman who presented with WBC 6.2 x 109/L, Hgb 10.2 g/dL, Hct 28.4%, and platelets 67 x 109/L. A bone marrow biopsy revealed a 70% hematopoietic cellularity with 65% blasts. Immunophenotyping showed aberrant expression of lymphoid-associated marker CD19. Cytogenetic analysis on a 72-hour culture of bone marrow cells supplemented with conditioned media was evaluated by G-banding at about the 400-band level. The patient's age, cytogenetics, WBC, and immunophenotype at diagnosis would seem to suggest a favorable prognosis, according to previous studies of prognostic indicators. She was treated with induction and consolidation chemotherapy, followed by myeloablative conditioning and autologous peripheral blood stem cell transplant (PBSCT). Despite multiple favorable prognostic factors, the patient relapsed 7 months after PBSCT. Translocation of chromosomes 8 and 21 is common in AML and is generally considered a good prognostic factor. We suspect that the effect of the 3q21 translocation in an otherwise favorable translocation of chromosomes 8 and 21 may be responsible for this patient's early relapse.
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U2 - 10.1016/S0165-4608(97)00438-X
DO - 10.1016/S0165-4608(97)00438-X
M3 - Article
C2 - 9648562
AN - SCOPUS:0032125671
SN - 0165-4608
VL - 104
SP - 66
EP - 69
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -