Translocation of protein kinase C activity may mediate hippocampal long-term potentiation

Raymond F. Akers; David M. Lovinger; Paricia A. Colley; David J. Linden; Areh Routtenberg

doi:10.1126/science.3003904

Translocation of protein kinase C activity may mediate hippocampal long-term potentiation

Raymond F. Akers, David M. Lovinger, Paricia A. Colley, David J. Linden, Areh Routtenberg^*

^*Corresponding author for this work

Psychology

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Abstract

Protein kinase C activity in rat hippocampal membranes and cytosol was determined 1 minute and 1 hour after induction of the synaptic plasticity of long-term potentiation. At 1 hour after long-term potentiation, but not at 1 minute, protein kinase C activity was increased twofold in membranes and decreased proportionately in cytosol, suggesting translocation of the activity. This time-dependent redistribution of enzyme activity was directly related to the persistence of synaptic plasticity, suggesting a novel mechanism regulating the strength of synaptic transmission.

Original language	English (US)
Pages (from-to)	587-589
Number of pages	3
Journal	Science
Volume	231
Issue number	4738
DOIs	https://doi.org/10.1126/science.3003904
State	Published - 1986

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title = "Translocation of protein kinase C activity may mediate hippocampal long-term potentiation",

abstract = "Protein kinase C activity in rat hippocampal membranes and cytosol was determined 1 minute and 1 hour after induction of the synaptic plasticity of long-term potentiation. At 1 hour after long-term potentiation, but not at 1 minute, protein kinase C activity was increased twofold in membranes and decreased proportionately in cytosol, suggesting translocation of the activity. This time-dependent redistribution of enzyme activity was directly related to the persistence of synaptic plasticity, suggesting a novel mechanism regulating the strength of synaptic transmission.",

author = "Akers, {Raymond F.} and Lovinger, {David M.} and Colley, {Paricia A.} and Linden, {David J.} and Areh Routtenberg",

year = "1986",

doi = "10.1126/science.3003904",

language = "English (US)",

volume = "231",

pages = "587--589",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

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T1 - Translocation of protein kinase C activity may mediate hippocampal long-term potentiation

AU - Akers, Raymond F.

AU - Lovinger, David M.

AU - Colley, Paricia A.

AU - Linden, David J.

AU - Routtenberg, Areh

PY - 1986

Y1 - 1986

N2 - Protein kinase C activity in rat hippocampal membranes and cytosol was determined 1 minute and 1 hour after induction of the synaptic plasticity of long-term potentiation. At 1 hour after long-term potentiation, but not at 1 minute, protein kinase C activity was increased twofold in membranes and decreased proportionately in cytosol, suggesting translocation of the activity. This time-dependent redistribution of enzyme activity was directly related to the persistence of synaptic plasticity, suggesting a novel mechanism regulating the strength of synaptic transmission.

AB - Protein kinase C activity in rat hippocampal membranes and cytosol was determined 1 minute and 1 hour after induction of the synaptic plasticity of long-term potentiation. At 1 hour after long-term potentiation, but not at 1 minute, protein kinase C activity was increased twofold in membranes and decreased proportionately in cytosol, suggesting translocation of the activity. This time-dependent redistribution of enzyme activity was directly related to the persistence of synaptic plasticity, suggesting a novel mechanism regulating the strength of synaptic transmission.

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DO - 10.1126/science.3003904

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SP - 587

EP - 589

JO - Science

JF - Science

IS - 4738

ER -

Translocation of protein kinase C activity may mediate hippocampal long-term potentiation

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