Translocation of protein kinase C activity may mediate hippocampal long-term potentiation

Raymond F. Akers, David M. Lovinger, Paricia A. Colley, David J. Linden, Areh Routtenberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

430 Scopus citations

Abstract

Protein kinase C activity in rat hippocampal membranes and cytosol was determined 1 minute and 1 hour after induction of the synaptic plasticity of long-term potentiation. At 1 hour after long-term potentiation, but not at 1 minute, protein kinase C activity was increased twofold in membranes and decreased proportionately in cytosol, suggesting translocation of the activity. This time-dependent redistribution of enzyme activity was directly related to the persistence of synaptic plasticity, suggesting a novel mechanism regulating the strength of synaptic transmission.

Original languageEnglish (US)
Pages (from-to)587-589
Number of pages3
JournalScience
Volume231
Issue number4738
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • General

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