TY - JOUR
T1 - Translocation (X;8)(q2?6;q21.3) in a case of systemic mastocytosis
AU - Zhang, Yanming
AU - Schlegelberger, Brigitte
AU - Weber-Matthiesen, Klaus
AU - Grote, Werner
AU - Bartels, Heinrich
PY - 1994/12
Y1 - 1994/12
N2 - Mastocytosis is a rare disease which occasionally progresses into mast cell leukemia or other myeloid neoplasms. Here we report on a patient with systemic mastocytosis who was found to have a clone with t(X;8)(q2?6;q21.3) and two copies of der(8)t(X;8). In accordance with these results, interphase cytogenetic analysis revealed that 93% of bone marrow cells contained three centromeric regions of chromosome 8. We suggest that the t(X;8) and the duplication of the translocation chromosome 8 may play a role in the progression of the diseases.
AB - Mastocytosis is a rare disease which occasionally progresses into mast cell leukemia or other myeloid neoplasms. Here we report on a patient with systemic mastocytosis who was found to have a clone with t(X;8)(q2?6;q21.3) and two copies of der(8)t(X;8). In accordance with these results, interphase cytogenetic analysis revealed that 93% of bone marrow cells contained three centromeric regions of chromosome 8. We suggest that the t(X;8) and the duplication of the translocation chromosome 8 may play a role in the progression of the diseases.
UR - http://www.scopus.com/inward/record.url?scp=0028641592&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028641592&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(94)90096-5
DO - 10.1016/0165-4608(94)90096-5
M3 - Article
C2 - 7828159
AN - SCOPUS:0028641592
SN - 0165-4608
VL - 78
SP - 236
EP - 238
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -
