Translocation (X;8)(q2?6;q21.3) in a case of systemic mastocytosis

Yanming Zhang, Brigitte Schlegelberger*, Klaus Weber-Matthiesen, Werner Grote, Heinrich Bartels

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Mastocytosis is a rare disease which occasionally progresses into mast cell leukemia or other myeloid neoplasms. Here we report on a patient with systemic mastocytosis who was found to have a clone with t(X;8)(q2?6;q21.3) and two copies of der(8)t(X;8). In accordance with these results, interphase cytogenetic analysis revealed that 93% of bone marrow cells contained three centromeric regions of chromosome 8. We suggest that the t(X;8) and the duplication of the translocation chromosome 8 may play a role in the progression of the diseases.

Original languageEnglish (US)
Pages (from-to)236-238
Number of pages3
JournalCancer Genetics and Cytogenetics
Issue number2
StatePublished - Dec 1994

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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