Transmitted antiretroviral drug resistance in newly HIV-Infected and untreated patients in ségou and bamako, mali

Almoustapha Issiaka Maiga*, Djeneba Bocar Fofana, Aichatou Chehy Maiga, Fodie Diallo, Zaina Ait-Arkoub, Fatoumata Daou, Mamadou Cisse, Yaya Dit Sadio Sarro, Aboubacar Alassane Oumar, Aliou Sylla, Christine Katlama, Babafemi Taiwo, Robert Murphy, Anatole Tounkara, Anne Genevieve Marcelin, Vincent Calvez

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The WHO recommends regular surveillance for transmitted antiretroviral drug-resistant viruses in HIV antiretroviral treatment (ART)-naive patients in resource-limited settings. This study aimed to assess the prevalence of mutations associated with resistance in ART-naive patients newly diagnosed with HIV in Bamako and Ségou in Mali. HIV-positive patients who never received ART were recruited in Bamako and Ségou, Mali. The reverse transcriptase (RT) and protease (PR) genes of these patients were sequenced by the "ViroSeq" method. Analysis and interpretation of the resistance were made according to the WHO 2009 list of drug resistance mutations. In all, 51/54 (94.4%) sample patients were sequenced. The median age (IQR) of our patients was 24 (22-27) years and the median CD4 count was 380 (340-456) cells/mm 3. The predominant subtype was recombinant HIV-1 CRF02-AG (66.7%) followed by CRF06-cpx (12%) and CRF09-cpx (4%). Four patients had mutations associated with resistance, giving an overall prevalence of resistance estimated at 7.9%. There were two (4%) patients with nucleoside reverse transcriptase inhibitor (NRTI) mutations (one M184V and one T215Y), two (4%) with non-NRTI mutations (two K103N), and one (2%) with a protease inhibitor mutation (one I54V). The prevalence of primary resistance in newly infected patients in Mali is moderate (7.9%). This indicates that the standard NNRTI-based first-line regimen used in Mali is suboptimal for some patients. This study should be done regularly to inform clinical practice.

Original languageEnglish (US)
Pages (from-to)182-186
Number of pages5
JournalAIDS research and human retroviruses
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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